DCA Sodium Dichloroacetate

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rjcrossley rjcrossley
(Inactive)

DCA Sodium Dichloroacetate

by rjcrossley on Sun Mar 18, 2012 09:47 PM

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Has any one heard of a chemo drug called DCA or  Dichloroacetate (DCA) – Sodium Dichloroacetate thay say it can replace Chemo and it can do the same job but with none of the  ill effects chemo has I saw this video on it when I saw this I found I can buy this now over the internet

http://www.youtube.com/watch?v=E_iqwHLaFW8&feature=conte

RE: DCA Sodium Dichloroacetate

by POOKIETRAIN on Mon Mar 19, 2012 01:33 AM

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RJ, I have seen this publicized on TV a few years ago and sort of forgot about it. Thanks for reminding us. Pharma-DCA.com seems to supply this molecule, however it doesn't recommend what quantity and frequency an individual should be taking. Any further information would be helpful. By the way, thanks for the apricot pit suggestion. I have been taking about 15 a day for a week now.

rjcrossley rjcrossley
(Inactive)

RE: DCA Sodium Dichloroacetate

by rjcrossley on Mon Mar 19, 2012 08:45 PM

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On Mar 19, 2012 1:33 AM POOKIETRAIN wrote:

RJ, I have seen this publicized on TV a few years ago and sort of forgot about it. Thanks for reminding us. Pharma-DCA.com "" target="_blank" rel="nofollow">http://Pharma-DCA.com " target="_blank" rel="nofollow">Pharma-DCA.com seems to supply this molecule, however it doesn't recommend what quantity and frequency an individual should be taking. Any further information would be helpful. By the way, thanks for the apricot pit suggestion. I have been taking about 15 a day for a week now.

I can get it here in Australia But I think For a few years now DCA been band by the FDA in the USA. But you can still get it in some of the other countries around the world And  you don't have to be good  at chemistry to make it your self DCA and the Warburg effect

DCA is a very simple molecule, deceptively simple. Basically, it is an analog of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms. Interestingly, it is only one chlorine atom off from trichloroacetic acid (TCA), a chemical we routinely use in the laboratory to precipitate nucleic acids and proteins from solution.

DCA has been around for a long time (which is why is it no longer under patent) and has primarily been used for inherited diseases of mitochondrial metabolism. Mitochondria are often (and correctly) referred to as the "powerhouses" or the "batteries" of the cell, because it is in the mitochondria that the main energy-containing molecule, ATP, is produced using byproducts of glycolysis and the Krebs citric acid cycle to generate a proton gradient across the mitochondrial membrane, which supplies the energy for the enzyme ATP synthase, which, true to its name, synthesizes ATP for use in the cell as a chemical source of energy. The key thing to remember about oxidative phophorylation is that it requires oxygen, whereas glycolysis does not. When there is insufficient oxygen, the end products of glycolysis end up being turned into lactic acid, which is one of the things that make muscles feel tired after a rapid workout that exceeds the capacity of the body to deliver oxygen to the tissues. The primary activity of DCA in cells is to inhibit the enzyme pyruvate dehydrogenase kinase. The result, to boil it down (and not to have to stress my knowledge of the basic biochemistry of glycolosis, the Krebs cycle, and oxidative phosphorylation too much) is to shift the metabolism of pyruvate from glycolysis towards oxidation in the mitochondria. To boil it down even further, DCA shifts the cell's metabolism from anaerobic to aerobic metabolism.

Why, then, would such an activity be useful as an anticancer therapy?

It all boils down to something known as the Warburg effect, which Otto Warburg first described way back in 1928 and reported inScienceback in 1956. Over the last five years or so, cancer researchers have been increasingly coming to appreciate the role of abnormalities in metabolism, in particular the mitochondria, in cancer. To put it briefly, many cancers (approximately 60-90%) favor glycolysis, even in the presence of adequate oxygen for oxidative phosphorylation, leading to a voracious appetite for glucose. Indeed, it is this very avidity of cancer cells for glucose that is the basis of the PET scan, which detects the high uptake of a radiolabeled form of glucose by cancer cells relative to the surrounding normal cells.

Over the last few years, there has been a sort of "chicken or the egg" argument about what is more important and what is the first abnormality leading to cancer. The traditional view has long been that mutations in DNA lead to the activation of protooncogenes into cancer-initiating and causing oncogenes and to the shutdown of tumor suppressor genes. Under this model, mutations leading to cancer also lead to the observations of abnormalities in metabolism. In the wake of the DCA furor, there have been data reported suggesting that the metabolic derangements may actually occur first or simultaneously with the mutations. p53, for instance, the granddaddy of tumor suppressor genes,can trigger the Warburg effectwhen mutated. Whatever the case, it is now fairly clear that abnormalities in cancer cell metabolism are very important in driving cancer growth and could well represent targets for cancer therapy. AS a result of these new data, studying the metabolism of cancer cells has become a much hotter topic of research than it has been in the past. Everything old is new again, it seems. Why cancer cells might have an advantage due to the Warburg effect is a matter of debate, although, given how tumors frequently outgrow their blood supply, being able to maintain themselves in low oxygen situations would be advantageous.

This fascinating basic science met the public in January 2007, when Michelakis and his colleagues at the University of Alberta in Edmonton published a seminal paper inCancer Cell. In the study, DCA was tested in multiple cell culture and rodent models of cancer. In rats, tumor weights in animals treated with DCA were approximately 60% lower than the tumors in the untreated control groups. The drug increased apoptosis, decreased proliferation, and inhibits tumor growth by acting on a critical enzyme that controls the switch between aerobic and anaerobic metabolism without harming non-cancerous cells. Even better, DCA had already been FDA-approved for mitochondrial disorders, meaning that using it in humans would be an "off-label" use of an already existing drug to test it in humans. Thus, the regulatory requirements were considerably easier to meet for early drug trials in cancer.


http://scienceblogs.com/insolence/2010/05/dichloroacetate_dc

rjcrossley rjcrossley
(Inactive)

RE: DCA Sodium Dichloroacetate

by rjcrossley on Sat Dec 21, 2013 09:02 PM

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On Dec 21, 2013 6:43 PM RayJenkins wrote:

Hello

Re cancer cure using DCA Sodium Dichloroacetate, there appears to be a number of web site now offering this.

I have bought from them all for myself, what concerns me is that according to the information on the internet all of this comes from China and while that may be no problem China has had a lot of bad press.

Finally I did find a company who produce their own pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com "" target="_blank" rel="nofollow">http://pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " 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" target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com the problem was that another company id called similar and is selling this at a ridiculous price.

I was told that it could be purchased from Sigma Aldrich but this is strictly only sold to business.

The people who I now use and who manufacture their own in Europe is pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com "" target="_blank" rel="nofollow">http://pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" rel="nofollow">pharma-dca.com " target="_blank" 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For anyone who needs to obtain this like myself I hope this helps and the price is good too.

Ray

Hi Ray thanks for the post. on  DCA Sodium Dichloroacetate  in the pass I to have  posted twice and Ive done it a few times it just happens  

I once look into DCA Sodium Dichloroacetate The only usefull good information I can find was on Wikipidia And I know that Wikipidia usuly not a reliable site but the information in it on  DCA Sodium Dichloroacetate is ok for us with this

http://en.wikipedia.org/wiki/Dichloroacetic_acid

I read on the site, how that,  DCA Sodium Dichloroacetate,  can help control cancer.  

Cancer cells generally express increasedglycolysis, because they rely on anaerobic respiration that occurs in the cytosol (lactic acid fermentation) rather thanoxidative phosphorylationin the mitochondria for energy (theWarburg effect), as a result ofhypoxiathat exists intumorsand malfunctioning mitochondria.[12][13]Usually dangerously damaged cells kill themselves viaapoptosis, a mechanism of self-destruction that involves mitochondria, but this mechanism fails in cancer cells.

A phase I study published in January 2007 by researchers at the University of Alberta, who had tested DCA on human[14]cancer cells grown in mice, found that DCA restored mitochondrial function, thus restoring apoptosis, allowing cancer cells to self-destruct and shrink the tumor.[15]

These results received extensive media attention, beginning with an article in New Scientist titled "Cheap, 'safe' drug kills most cancers".[14] Subsequently, theAmerican Cancer Society and other medical organizations have received a large volume of public interest and questions regarding DCA.[16] Clinical trials in humans with cancer have not been conducted in the USA and are not yet final in Canada, emphasizing the need for caution in interpreting the preliminary results.[16][17]Have a very marry christmas

My name also Ray

sharoncrayne sharoncrayne
(Inactive)

RE: DCA Sodium Dichloroacetate

by sharoncrayne on Tue Dec 31, 2013 07:51 PM

Quote | Reply

The issue of DCA (a byproduct of TCE) is NOT that simple, nor without potential serious neurological complications as some uninformed individuals suggest.

I guess if someone is in Stage 4, everything is fair game to try. Why not?

Otherwise, be very careful with a compound as powerful as DCA that has never underegone serious clinical trial (at any level from what I can see).

Even Michelakis has been very conservative in his comments about DCA, as well he should be.

Do yourself a favor and read the British Journal of Cancer (2010) article on DCA...last paragraph of this study.

HMM

RE: DCA Sodium Dichloroacetate

by rylee on Sat Jan 11, 2014 08:39 AM

Quote | Reply
Yes, be very careful with DCA. My daughter was in the study of Dr. Michelakis 's. She was taken out of the study because of extreme peripheral neuropathy and it has been four years now since she has been off the DCA and she still has some neuropathy. If you start to experience neuropathy take a break from the DCA or lower the dosage. My daughter has a brain tumor and my husband has prostate cancer so I am on both discussion groups.

RE: DCA Sodium Dichloroacetate

by jimmy-goat on Sat Jan 11, 2014 08:48 AM

Quote | Reply

If you take it then you need to add other things to help reduce side effects and make it work better like; B1, Alpha Lipoic Acid, CoQ-10, Acetyl-l-Carnitine, N-acetylcysteine and Avemar. Sadly no big drug company will fund any major study because its not under patient any more

RE: DCA Sodium Dichloroacetate

by tsimons on Sun Jan 10, 2016 02:12 PM

Quote | Reply

How is the dca working with the prostate cancer? I have a friend with stage 4 and was curious. There only giving him a few months. 

RE: DCA Sodium Dichloroacetate

by ebarkley12 on Wed Feb 03, 2016 03:27 AM

Quote | Reply

On Jan 10, 2016 2:12 PM tsimons wrote:

How is the dca working with the prostate cancer? I have a friend with stage 4 and was curious. There only giving him a few months. 

I have metastasized Prostate Cancer with Castration Resistance ( stage 4 ++).  Just stated taking the DCA about a week ago. I am taking about 18mg / Kg of my weight , with B1 & black tea.  I let you know if working in a month.

RE: DCA Sodium Dichloroacetate

by arvid on Thu Mar 10, 2016 03:25 PM

Quote | Reply

Was diagnosed with prostate cancer metastasized to the pelvic bone and spine 2 years ago. I bought from these: http://www.dcalab.com/ . DCA worked for me, but I drank as much as 4grams a day (about 40mg/kg). This is a huge dose as the usual recommendation is 24mg/kg. Started with 2grams (20mg/kg) but since I did not experience any side effects and already saw some improvements I decided to increase it. Also used hyaluronic acid for bone strengthening since it metastasized to the bones. Treatment took 3 and a half months. My PSA started to drop pretty quick (from 157 before treatment to about 50 at the end of month 3). It continued to fall after the treatment (and is now <10), tests showed complete remission and I felt much better.

Look up Medicor Cancer Centers statistics, they use DCA therapy and their results are quite good considering they mostly treat hopeless patients:
http://medicorcancer.com/dca-therapy-data/ 

They take paid consultations via email from anyone.

What you basically need to know before using is that you need to take breaks (2 weeks DCA, 1 week break) since it builds up in your cells. Also that about half of people experience side effects (reversible peripheral neuropathy, like arm shaking, goes away after you stop taking it) and that you need to take vitamin B1 and Alfa Lipoic acid supplements to reduce it.

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