Anyone used 3bp (3-bromopyruvate)?

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RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Tue Mar 10, 2015 05:16 AM

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Can you share who your doctors are who are familiar with these issues?

RE: Anyone used 3bp (3-bromopyruvate)?

by howardA on Tue Mar 10, 2015 09:57 PM

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danielus good day to all..i started doing my first tests in te middle of radiation and chemo  went into to that round at 125. was  figuring out how to handle it and get it into my body , doing a 1/4 gram a day for 40 days the last half of those 40 days i pretty  much had a handle on it 3 weeks after the radiation my markers were 450 .   this told me that nothing was working , went to 1 gram a day via nebulizer . i mix my 3bp dense 3 mole solution just because it takes a lot of time to inhale the mist , about 1 hour . alkalize with sodium hydroxide , tried baking soda thats a none starter for me . happy to here what someone else is doing to make that work .

stayed on it as the markers rose to 1950 over the next 6 weeks . on the ninth week they started back down 1550 , 550, 205  and 175 . at this point ran out of product and 6 weeks out the 850 #.   this might seem scary , but i feel fine ,  thats the question i ask myself every morning. how do i  feel?

my tumor started in the bile tub , surgery removed that , then showed up in a limp node and has spred into the liver all very small and hard targets to hit.

have been on somewhat of a ketogenic diet since my markers were at 52 , if cancer likes it , it dosen't get any .  if cancer dosen't like it it gets a double dose ,if it won't hurt me double it again.

on the salinomycin front  i haven't found any hard #s on dosege just at 1mg per kilo they can kill test animals with continus use . it has a half life of 12 hrs and gone in 24 this is probably the reason for every other day treatment down in bogota .  also a study    evaluation of zinc against salinomycin toxicity in broiler pigs , done on 1-15-02. my dose here is (not to be talked about in front of the children ) is 330mg every other day with lots of zinc  the nexy day .

RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Fri Mar 13, 2015 05:16 PM

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Two of my Southern Cal doctors are boning up on the DCA HBO metformin Keto protocol. Costa mesa and Pasadena. They will probably be up to speed in a couple of months for me to do it. FYI in case anyone else is interested.

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Fri Mar 13, 2015 06:37 PM

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RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Fri Mar 13, 2015 06:39 PM

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"The EC50 of metformin were 15,200,000 times, 448 times, 67 times, 26 times, and 25 times higher than phenformin in B16F10 (melanoma), MCF7 (breast cancer), CT26 (colon cancer), A549 (lung cancer), and DU145 (prostate cancer), respectively."

Wow!

RE: Anyone used 3bp (3-bromopyruvate)?

by Genelle on Fri Mar 13, 2015 07:06 PM

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They can get metformin covered by insurance. Not sure about Phenformin.

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Mar 14, 2015 02:02 AM

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I am interested to hear the opinions of those on this thread concerning the safety of phenformin as an anti-cancer agent.

There has been considerable excitement raised recently about the use of metformin as an anti-cancer agent.

Yet, "Phenformin is a 50-fold more potent inhibitor of mitochondrial complex I than metformin. However, Phenformin was associated with a higher incidence of lactic acidosis,"

The risk of lactic acidosis in metformin users is about 3 per 100,000 patient years while it is roughly 64 per 100,000 patient years in those using phenformin. Lactic acidosis has a mortality rate of about 50%. Yet, there has been some recent encouraging treatment successes with lactic acidosis

(e.g. Efficacy of continuous venovenous haemofiltration (CVVH) in the treatment of severe phenformin-induced
lacticacidosis
Nephrol Dial Transplant (1998)13:1012-1015).

[Spermidine (from grapefruit0 might be an effective treatment.]

Many (in some articles all) of the patients who developed lactic acidosis had co-morbidities (especially acute heart failure and acute renal failure). Some diagnoses of lactic acidosis took some time to be made as it was not clear on presentation what was wrong.

In addition, the phenformin dosage for cancer has yet to be optimized.

"Considering cancer therapy would be quite different from its priorclinical use for diabetes, we could optimize dosing and duration of Phenformin treatment to reduce serious side effects."

Synergistic Effect of Phenformin in Non-Small Cell Lung Cancer (NSCLC) Ionizing Radiation Treatment

Given this information, would phenformin be preferred over metformin?

RE: Anyone used 3bp (3-bromopyruvate)?

by skaran on Sun Mar 15, 2015 04:05 AM

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Most of the studies going on now are being done on Metformin but I did find a resent one comparing the two. 

http://www.pnas.org/content/111/29/10574.full

There are some slight difference on how they effect certain metabilites, and which one would be the most effective on CSC. There needs to be much more done on this line of research to know if Phenformin is better at targeting CSC or just a stronger biguanide.

But in another study:

http://www.atmjournal.org/article/view/3965/4955

I'm quoting here: emphasis in italics and bold print and underline are mine.

"Recently, the inhibitory activity of metformin on CSC phenotypes and functions have received more attention. We showed that metformin treatment attenuates the CSC phenotypes and functions such as CSC self-renewal capacity and CSC signature and its mediators, consistent with attenuation of cell proliferation and migration in pancreatic cancer drug-resistant cells (64). It has also been reported that metformin selectively diminished the expansions of CSC clones through induction of apoptotic function and the inhibition of CSC mediators and markers, consistent with attenuation of tumor growth in animal models. However, non-CSC tumor cells only showed cell cycle arrest, but was unable to eliminate the cells when treated with metformin (65). These results may indicate that CSCs or CSC-like cells appear to be more vulnerable to metformin treatment than non-CSC tumor cells. The reason why the CSC cells appear to be more sensitive to metformin may be due to its primary mechanism on glucose metabolism. It has been noted that under the conditions of glucose deprivation, metformin treatment increases apoptotic cell death in breast cancer cells, while under the conditions of high level of glucose, metformin treatment mostly caused cell cycle arrest without the signs of apoptotic cell death in breast cancer cells (66). High levels of glucose has also been reported to increase the percentage of the side population (SP, CSC-like) cells, consistent with the activation of Akt pathway and suppression of AMPK activation, leading to the elevation of ABCG2 expression (67). These data suggest that CSC cells may be more sensitive to metformin, potentially due to its modulation of glucose homeostasis."

And we're back to the fact that this works best in cancer stem cells when we starve them and they are on the metabolic edge.  (aka R-KD)

RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Mar 15, 2015 11:29 AM

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I think Metformin is clearly an element to be considered as a part of an anti cancer treatment strategy. Is is typically given to every cancer patient at some of the very well known anti-cancer clinics in Germany.

My question now to all is what to expect when combining Metformin and even more Phenformin with 3BP. Specifically Phenformin seems to lead to lactic acidosis. What is the mechanism behind? Will this lead to increased expression of MCT transporters in the normal cells as well? And if yes, will 3BP start to kill normal cells as well?

RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Sun Mar 15, 2015 11:33 AM

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Should we combine DCA with Metformin? DCA helps to bring pyruvate back on track to mitochondria while Metformin inhibits mitochondria.

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