Anyone used 3bp (3-bromopyruvate)?

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RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Mon Jan 21, 2019 06:47 PM

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JohnnyP, I am sorry for this recent setback. It is likely obvious to you now that educating yourself about the various options available is the rational strategy.

The focus of mainstream medicine has been on a highly rigorous, highly regulated scientific approach which has resulted in a very slow rate of progress. When you recognize this perspective, you no longer need to argue with them. If they do not want to talk to you about nutrition, don't be offended! Nutrition is not the treatment perspectice that they have been taught.

The CA-15-3 test that you mentioned is based on MUC1. MUC1 vaccines have been in clincal trials for decades and decades. In mice these vaccines had currative effects, while in humans the results have been less successful. However, given the metabolic metro map that I posted recently it is not overly difficult to see that obstrcuting any one pathway in this network will only have a marginal effect. Clearly multiple nodes in the network need to be targeted at the same time.

Even E260 which targets the mitchondrial cancer specific protein Fer needed ketogenic diet to demonstrate remarkable efficacy.  Given this I think that the FDA should allow some amount of market access under Right To Try to those drugs that have not been successful in phase 3 as monotherapies. 

One of the latest treatments that has raised some interest on D's forum is Metformin-Syrosingopine. Shutting down NAD+ recycling definitely could have significant anti-cancer potential. 

Best Wishes, Jcancom

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Tue Jan 22, 2019 07:44 PM

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Wow, that is cool.  Two common, safe, affordable drugs all oncologists are probably familiar with when used for their original purpose.  But, very scary (to them) when used off label.

I wonder if Dr. Nagourney is trying this in his clinic in Long Beach.  He's already using Metformin.

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Jan 23, 2019 02:30 AM

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This is over 2,000 year old medicine! Rauwolfia vomitoria

I would certainly be interested in seeing the full armamentarium of the Neanderthals or other early peoples. Think of what we could learn from them!


RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Wed Jan 23, 2019 07:10 PM

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I found a 17 page paper on Metformin and Syrosingopine:

https://www.cell.com/cell-reports/pdf/S2211-1247(18)31806-0.pdf

It looks like there is still a lot of work to do on it.  What has Daniel done with it so far?

RE: Anyone used 3bp (3-bromopyruvate)?

by peggyznd on Wed Jan 23, 2019 07:39 PM

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The Neaderthals kept poor records and didn't live very long; I do not think that their armamentarium included much more than spears and clubs.  

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jan 24, 2019 01:37 AM

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JohnnyP, D has traced this to a natural product that is apparently available and has a considerable amount of supporting research. Check D's forum for the details (use search term syrosingopine).  

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Jan 24, 2019 02:35 AM

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I want the thread to be aware that Cancer Compass is soliciting suggestions on how to improve the thread software. I had been wondering when they might upgrade the functionality of the software. Yet, for some unknown reason they have not posted to all of the threads a request to provide such suggestions.

Here are a few of my ideas for software improvements:

-allowing for collapsable threads (This would allow for parallel conversations and promote a sense of intra-thread competition.),

-allowing ratings for posts (up votes, down votes, emoticons, etc.),

-including a search feature,

-giving posters their own blog space from their user page,

-having a download feature where an entire thread could be downloaded, and

-giving posters the ability to make annotations to the thread {A great feature would be to allow posters to create an index in which they maintained a time series for the highs and lows of the thread. Readers could then click on this time series to see a particular post. This would help highlight the most important information on our thread. Without such organization our thread has become increasingly difficult to follow.}

Any other suggestions? Please post them!

This is a great time to express our gratitude to Cancer Treatment Centres of America for hosting this forum and this thread and allowing posters freedom to post comments that from time to time might not align with their organization's self-interests.  

Cancer is a very frustrating subject to post about as only glacial progress occurs with the passage of time. Nonetheless, I hope that through Cancer Compass permitting our posts to reach this thread, our comments will be of value to cancer patients in need.       

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Thu Jan 24, 2019 03:36 PM

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Doing a search I found this post about it here:

https://healthunlocked.com/advanced-prostate-cancer/posts/13

"cesanon
in reply topjoshea13
a month ago

Talked to my Doc about syrosingopine.

He thought it was a really bad idea. There is a reason no one uses it anymore.

It has really bad side effects. No one even appears to sell it anymore."

How bad is "really bad" compared to chemo, etc?

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Thu Jan 24, 2019 03:51 PM

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Hmm, a thread about "Methformin and Syrosingopine" on cancercompass.  Ten replies from 1/17 to 1/18:

https://www.cancercompass.com/message-board/message/all,9444

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Thu Jan 24, 2019 10:40 PM

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Is anyone going to the Metabolic Health Summit in Long Beach this weekend?

I considered buying tickets for one of our oncologists but my wife said it would be a waste of money.

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