JohnnyP, this is very encouraging news!
After all of these years we are now starting to see a number of successes emerging. My perception is that we have managed to unlock a part of the cancer puzzle: i.e., related to amplifying response to chemotherapy through metabolic stressing. However, it is still unclear to us how to go about achieving this magnification without chemo.
Apparently Dayspring considers 3-BP to be its leading edge treatment that is then supported by a range of other metabolics. Yet, it is not obvious how they have made 3-BP so effective. What formulation are they using? What combinations?
I am glad that you took note of the clinical situation and made appropriate adjustments. Oftentimes people seem to go full steam ahead with the same game plan even when the situation is heading south. If getting out of a wheelchair has become the measure of success, it is urgently important to think what alternatives might be attempted to move the goal posts upfield.
I simply do not understand the mentality that you mentioned of doctors who appear to have no interest in interacting with the research literature. I appreciate that there is something called reality where people go to work at 9 am, clock out at 5 PM, pick up their paycheck, have a nice family dinner and then catch up on their social media, though some level of engagement in the enormous cancer literature does not seem an unreasonable request of modern medicine. Life based 100% on attendance no longer rings true. I realize that this allows for maximal billable minutes, though all that you have then is hollow presentism.
I am at a loss as to why the metabolic strategies that you have mentioned have not been incorporated into current standard of care. It is quite jarring when you go to the pancreatic cancer threads on Compass and read people who feel that there situation is completely hopeless, while the Turkish clinic published reasonably favorable results in pancreatic cancer patients over a year ago (as you linked).
JohnnyP, I am so glad that you continue to be mentally engaged in trying to unravel the enigma of cancer. If I had to distill the thread into one thought that would help improve the outcome of cancer treatment that would be at the top of the list or very close to it.
Going to the metabolic conference was a very good idea! The website gives me the impression that it would be great fun and an enormous learning opportunity! I am sure that I would be doing an all night cram session for the final day final exam! What a great way to learn and live! Educate yourself about something that you are passionate about, meet up with a bunch of people who are also stoked, Jump on a plane, Are they fundamentally opposed to accepting US dollars? No?, great let the learning begin! (Yes? Get back on the plane).
Metabolic Dysregulation is the central force creating a massive medical catastrophe in the modern world. Cancer, Alzheimer's, diabetes, heart disease, obesity, seizure disorder, stroke; it's all largely metabolic. Modern living is even making our pets sick! We clearly need to energize a grassroots consciousness raising movement that embraces metabolic medicine.
The line up for the Conference looks solid. Diversity of background truly is a strength here as the clues related to our modern metabolic crisis are increasingly becoming obscured. Possibly including a historical perspective would be insightful. There is no precedent for the per captia level of caloric intake now being consumed in the Modern World.
From the conference speakers, I would be espeically attentive to the exercise physiologists. I am very interested in how ketogenic diet/ glucose lowering through aerobic/anerobic exercise and lactate increase through anerobic exercise might combine into a cancer treatment. Report to the thread your impressions ... Please!
Of late I have been reconsidering my general orientation to cancer treatment. Until very recently I thought that the best cancer strategy would be to go with a super duper overwhelmingly powerful high tech treatment: minicells, X-Ray PDT, oncolytic virus, metabolic blocker (e.g. E260) etc. I am no longer as sure that this would represent a long-term strategy.
Once cancer has went metastatic, cure in the strictest sense might no longer be possible. In dogs they found that a metabolic approach was often effective as a treatment, though dogs who then went back to typical Western canine lifestyles (obesity, high carbs, low activity {basically the lifestyle of Western people}) would have recurrences.
My position is now shifting toward the idea that a cancer diagnosis should initiate a life long orthogonal lifestyle transformation. At its most basic this is a highly simple strategy: The lifestyle that gets people into an unhealthy state needs to be changed. Do the opposite to move back towards health. Many of the well known cancer treament plans embrace this exact philosophy. Eat right, exercise, early to bed etc. . Healthy living is more powerful medicine than is generally understood.
It is so great to hear that you have some bed time reading. Perhaps you could bring it to the beach with you while you catch a few waves! This is a revolutionary time of mass learning! It is so exciting!
The time of joyful high school students throwing away their caps with the expectation that their days of learning are over is over. We are witnessing a profound transformation towards life-long learning. Increasingly the very intellectal legitimacy of our most respected professions is being called into question. How much longer will questions asked about metabolic cancer treatments be allowed to be answered with "I don't have time", instead of this being interpreted as meaning I don't know?
Some more bedtime reading. The Warburg Trap looks especially interesting. It is quite exasperating reading many of these articles because often they will slightly tweak drug combinations that we are very familiar with and reveal a new and possibly more powerful treatment.
https://www.nature.com/articles/s41421-018-0033-2
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=25839&path[]=80775
Best Wishes and Keep on Learning! Jcancom