Anyone used 3bp (3-bromopyruvate)?

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RE: Anyone used 3bp (3-bromopyruvate)?

by dumbcritic on Sat Feb 16, 2019 01:28 AM

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On Feb 11, 2019 5:39 AM JohnnyP wrote:

J:

I watched this video several months ago.  It's part of a series of six videos from a 2017 conference in Paris.  Most of them were pretty good, from people I've seen before.

This one by Ernest G. Hope is on immunotherapy that targets the blood vessels that feed the tumor:


https://www.youtube.com/watch?v=kDkuwW7Bqho&t=445s" target="_blank" rel="nofollow">https://www.youtube.com/watch?v=kDkuwW7Bqho&t=445s

Very exciting stuff, so I did a search on where to go get it, and found nothing.

The Holy Grail and no one is using it?

One of the slides in his presentation he says it's patented, so I did an advanced patent search under his name and found one patent, EP1231840B1.  The patent was granted in 2009, but is no longer in force. Status is "Ceased":

https://www.ipo.gov.uk/p-ipsum/Case/ApplicationNumber/EP0098 7995.8"" target="_blank" rel="nofollow">https://www.ipo.gov.uk/p-ipsum/Case/ApplicationNumber/EP0098 target="_blank" rel="nofollow">https://www.ipo.gov.uk/p-ipsum/Case/ApplicationNumber/EP0098


I posted a comment to that effect below the video, but all comments are now gone.

To me, it looks like a "vaporware" presentation about a lot of work he did that didn't pan out.

Anti-angiogenic vaccines have been tested in the past [1,2] as have CAR-T cells [3]. One company (Batu Biologics) plans to test another vaccine in patients soon.

Refs:

1 https://www.ejcancer.com/article/S0959-8049(07)00850-7/fulltext

2 https://onlinelibrary.wiley.com/doi/full/10.1111/cas.12055

3 https://clinicaltrials.gov/ct2/show/results/NCT01218867

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Mon Feb 18, 2019 01:37 AM

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Page 500!

Yeah, this is exciting! Moving toward post 5000 with vitality and confidence!

The 3-BP story line continues to advance forward and upward! I can hardly wait to see the clinical trial finally start.

critic, I came across a very interesting article that talked of how rhodamine ( I believe it was), can clear normal cells within a few hours, though this can take days for cancer cells. It has occurred to me that this might be of considerable relevance as an anti-cancer strategy. For example, one could imagine a prodrug loaded onto something such as rhodamine that might be allowed to clear normal cells and then an activating drug administered once such clearance had been accomplished in the normal cells but not the cancer cells (other combinations are also imaginable). Are you aware of any cancer therapies that use this strategy?  

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Tue Feb 26, 2019 09:52 AM

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J:

I was reading the comments below a youtube video, and someone posted the link to an interview of Dr. Slocum from Istanbul:

http://p5hv.com/dr-abdul-slocum/

The page apologized for the poor audio quality and posted a transcript of it as well., so I read that rather than try listening to the audio.

One of the protocols at their clinicis is HBOT (hyperbaric oxygen).  The interviewer asked "at what pressure, 29psi?"  Dr. Slocum replied 7psi.

Can a soft chamber get to 7psi?  That would be much cheaper and possibly could be done at home.

A local place quoted me ten sessions in a hard chamber for about $1000.

It's a very good interview.  You can tell Dr. Slocum is doing a little tap dancing, working in several times that they of course employ standard of care, but lower dose chemo, etc.

At the bottom  of the page the interviewer has links to interviews with Seyfried and Travis Christofferson.  Listening to the Seyfried interview at the moment.

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Tue Feb 26, 2019 01:45 PM

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Listening to Travis Christofferson now.  Apparently he has started a clinic in London:

https://careoncology.com/

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Tue Feb 26, 2019 01:49 PM

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Correction, he is working with them to bring a branch to the US.

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Tue Feb 26, 2019 02:02 PM

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They use a cocktail of four repurposed, or off label, drugs with known safety profiles.  He spoke about metformin, statins, albendazole, and doxyclycline.

The clinic they opened is in Rapid City, SD.  I think that's where Dr. Annette Bosworth is (Dr. Boz).  She has a great story of helping her Mom survive cancer, based on the ketogenic diet.

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Tue Feb 26, 2019 02:14 PM

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Nope, Souix Falls.  Only a five hour drive.  :)

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed Feb 27, 2019 01:27 AM

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JohnnyP, thank you for reactivating the thread!

As you are no doubt aware, the thread has had many times of near manic excitement, often accompanied with many exclamation marks (!!!!!) {In honestly that has mostly been me}, though usually the follow-on clinical relevance of these eras have been non-existant. 

Now, however, for me anyways, the silences, are more profoundly meaningful (as is frequently true). D's forum is reporting what seems to be patient after patient with     stage IV that is doing surprisingly well. Admittedly, this is in the context of heroic treatment regimens that typically involve near 24/7 infusions or other treatments, yet in all of the years we have never seen such results before.

The entire conception of there being millions (billions?) of types of cancer, or even more ambitiously a type of cancer associated with each patient does not appear evident in what we are witnessing. Further, the hypothesis/mantra that cancer is a metabolic disease is being demonstrated to us over a range of cancers. I do not want to overemphasize these results, though my prolonged recent silences might be interpreted in that way. Nonetheless it needs to be clearly stated that the current reports are only less than a year in duration and generally are in the context of a chemo base treatment.

However, it also needs to be noted that our results closely parallel and confirm the results from the Turkish clinic. They have an extensive patient dataset that has been maturing now for roughly ten years.

3-BP has of yet not been clearly found to be a substantial contributor to the success, though its research literature continues to expand. Recently, a synergistic combination was found with CA-IX using acetazolamide. The finding was not entirely unexpected, yet it can be added to an ever increasing list of FDA approved drugs and others that can exhibit synergism with 3-BP.

While it should not be automatically assumed that such combinations will be safe in humans, it is still very encouraging that a wide range of options could be available for combining with 3-BP. One might imagine cycling through a range of them possibly while also being monitored with real time imaging. With 3-BP you certainly know when you hit the right combo: the tumor metabolism stops (immediately!). 

There are still a range of combos that have yet to be explored. I am espeically interested in seeing keto diet/caloric restriction and/or methylglyoxal with 3-BP. These traditional mainline metabolic strategies would seem the most obvious ones to explore in the near future. It will also be of interest to see how 3-BP will create its own ecosphere. I would guess that many treatments would appreciate having the protection of 3-BP to provide cover and then amp up its treatment power (something such as a targeted paracetamol would be a natural).

We have uncovered a nearly endless literature on metabolic approaches and finally have found approaches that can be used to unlock benefits for patients. It is comforting that we finally appear to be helping those in need.

Best Wishes

RE: Anyone used 3bp (3-bromopyruvate)?

by Caddy on Wed Feb 27, 2019 03:17 AM

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 it's mebendazole, not albendazole, I think. I was on the Care Oncology protocol but stopped as it seemed to have no effect on my prostate cancer.

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Wed Feb 27, 2019 04:51 AM

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I just googled to see, both are being tried for cancer.

Very sorry to hear their treatmene didn't work for you.  Are you doing keto, etc?  If the tumors show up on a PET scan, keto should help.

Did you do HBOT and hyperthermia?

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