Anyone used 3bp (3-bromopyruvate)?

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RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Tue May 14, 2019 11:50 PM

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JohnnyP, it is such a difficult struggle, though in many ways you are on the right track: intensify and rotate through metabolic treatments. Seek out metronomic metabolic therapies.

Metronomics allows you to fight back 24 hours per day against cancer which does not seem to take many breaks. This was one of the larger insights that we had on D's forum. Might be a good time to give some thought to the updated approach to lower glucose levels that I quoted a ways back on thread, suggested that there was such a clinical protcol that might be portable from existing medical procedures.

Quite startling how many alternative and even traditional chemo and other therapies ultimately have metabolic mechanisms of action. We have mentioned this on post before, yet it bears repeating: the researchers who pioneered 3-BP deserve a Nobel prize.

Most people are still largely clued out about the importanance of 3-BP. However, all you need to do is go back to the early 2000s and see the citations build up for 3-BP and DCA. Shutting off cancer metabolism in the preclinical models caught the attention of a substantial proportion of the oncology research community. Now we are seeing clinical successes such as the Turkish clinic and elsewhere.    

Actively engaging with the research and making comments to the treatment team is a big asset for you. It is difficult to understand why so many retreat into being a patient when the traditional (i.e., mainstream) medicine has yet to be optimized. Keep up your spirits JohnnyP! There has been a great deal of success of late on D's forum. I can hardly wait to see what new insight might emerge there.

Best Wishes, Jcancom

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu May 16, 2019 03:21 AM

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critic, thank you for posting the link!

I felt so much love and joy when I went to the url. When I posted about the conference earlier on thread I was very impressed with how well all the details had been attended to. My impression from the website is that the conference was a massive success. Success feels great! There is a growing positive energy associated with metabolics as it is becoming increasingly self-apparent that this is a way forward in cancer management.

Earlier when posting about the conference I reached poetically to foresee an era of metabolic medicine. This is being manifest. The published results from Turkey for the lung cancer patients were dramatic. Other less formal replications have been observed.

At the same time, the potential metabolic toolkit continues to expand; it is remarkable. I had snoozed through Fenbendazole quite a few times on D's forum, though we have now heard strong reports about that one and another drug in the same class. Mebendazole is mentioned on the conferernce site. There is also mention of Oxaloacetate; I have also had that one on the backburner for a while.

It is almost too much to believe-- Do ALL the intermediates and targets in the main energy pathways have therapeutic potential (citrate, the OXPHOS complexes, oxaloacetate, GLUTs, MCT-1, ... . ) ? We started building up a list of anti-metabolics on D's forum and it kept growing and growing!   

The broad metabolic position that has been consistently advanced on thread has largely been verified by ongoing clinical and other research. We were right.    

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Mon May 20, 2019 01:25 AM

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J:

I was watching another D'Agostino video yesterday.  It's pretty long, and he runs out  of time at the end when he gets to the cancer portion of his talk, but he does mention keto and HBOT, IV C, 3BP, 2DG, DCA, etc.  I have it cued up:

https://www.youtube.com/watch?v=9AQ5ut5toy4&t=52m13s

He says vitamin C doesn't work by itself, "but it is promoted".  He does on to say it works with other modalities.

At another point in the video he mentions patents, so I did a patent search on his name and found this title:

"Targeting Cancer with Metabolic Therapy and Hyperbaric Oxygen"

I haven't read it yet, and I don't know if it has issued.

https://patents.google.com/patent/WO2014085652A1/en?oq=ininventor:dominic+ininventor:d%27agostino

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Mon May 20, 2019 08:48 AM

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critic:

Darn, looks like I missed out on the videos.  $30 to view now.  It's for a good cause, so I will probably spring for it later this week.

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Mon May 20, 2019 12:49 PM

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I followed up on a lead dropped by Dr. D'Agastino.  He mentioned Dr. Lewis Cantley, so I did a search of him at the same conference and found his talk on PI3K inhibitors:

https://www.youtube.com/watch?v=S395qX6G6HM

WOW WOW WOW.

See PET scan at 16:25 and graph at 36:51.  Note that patient must not be on insulin and must be on a ketogenic diet to keep insulin low.

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Mon May 20, 2019 12:53 PM

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Dr. Cantley says the tumors are still there, visible on CT scan,  but no longer visible on PET, so their glucose uptake has been drastically cut.  He says the patient survived another 18 months.  He did not comment on her diet.

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Wed May 22, 2019 02:17 AM

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JohnnyP wanted to make sure that you were aware of this one. Very exciting in metabolic research when things are always popping out of nowhere. We have been aware for quite some time of the vitamin C doxy combo, but this one looks even better. You can never be quite sure when they might hit the combo that has extreme effectiveness. Those who have been oberving this for a while can recognize that there are a relatively small number of possible treatments that are constantly recombined into yet more powerful therapies.  

https://www.ncbi.nlm.nih.gov/pubmed/31002656

RE: Anyone used 3bp (3-bromopyruvate)?

by dumbcritic on Sun May 26, 2019 12:01 AM

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On May 20, 2019 12:53 PM JohnnyP wrote:

Dr. Cantley says the tumors are still there, visible on CT scan,  but no longer visible on PET, so their glucose uptake has been drastically cut.  He says the patient survived another 18 months.  He did not comment on her diet.

The FDA has approved Novartis' Piqray (alpelisib), a PI3Ki, for the treatment of HR+, HER2- PIK3CA mutated advanced or metastatic breast cancer in patients who have progressed after receiving endocrine-based therapy. If the (R-)KD improves efficacy (which it should) it makes sense to add on ketone supplementation and HBOT [1-3].

Refs:

1 https://journals.plos.org/plosone/article?id=10.1371/journal

2 https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.28809

3 https://journals.plos.org/plosone/article?id=10.1371/journal

RE: Anyone used 3bp (3-bromopyruvate)?

by dumbcritic on Sun May 26, 2019 12:10 AM

Quote | Reply

On May 22, 2019 2:17 AM Jcancom wrote:

JohnnyP wanted to make sure that you were aware of this one. Very exciting in metabolic research when things are always popping out of nowhere. We have been aware for quite some time of the vitamin C doxy combo, but this one looks even better. You can never be quite sure when they might hit the combo that has extreme effectiveness. Those who have been oberving this for a while can recognize that there are a relatively small number of possible treatments that are constantly recombined into yet more powerful therapies.  

https://www.ncbi.nlm.nih.gov/pubmed/31002656 "" target="_blank" rel="nofollow">https://www.ncbi.nlm.nih.gov/pubmed/31002656 " target="_blank" rel="nofollow">https://www.ncbi.nlm.nih.gov/pubmed/31002656

Some early data on IACS-010759 (a small-molecule inhibitor of complex I) will be presented at ASCO [1]. The trial is recruiting at M.D. Anderson, Texas [2].

Some info from the abstract shows that of the 18 pts treated, 7 had a best response of RECIST stable disease. One pt with heavily pretreated CRPC achieved RECIST partial response with resolution of CRPC related pain.

Refs:

1 http://abstracts.asco.org/239/AbstView_239_253503.html

2 https://clinicaltrials.gov/ct2/show/NCT03291938

RE: Anyone used 3bp (3-bromopyruvate)?

by dumbcritic on Sun May 26, 2019 12:16 AM

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On Apr 09, 2019 11:03 PM dumbcritic wrote:

The trial (NCT01976585) testing this in low-grade lymphoma is still recruiting. Another (NCT03789097) is open to patients with either NHL, metastatic breast or head and neck squamous cell carcinoma and adds Keytruda.

https://medicalxpress.com/news/2019-04-treatment-tumors-canc er-vaccine-factories.html"" target="_blank" rel="nofollow">https://medicalxpress.com/news/2019-04-treatment-tumors-canc target="_blank" rel="nofollow">https://medicalxpress.com/news/2019-04-treatment-tumors-canc

JohnnyP, here are links to two other trials which may be of help to your wife [1,2].

Refs:

https://clinicaltrials.gov/ct2/show/NCT03412877

https://clinicaltrials.gov/ct2/show/NCT01174121

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