Survival rates for Glioblastoma Multiforme Stage IV

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RE: Survival rates for Glioblastoma Multiforme Stage IV

by TammyHill on Mon Apr 17, 2017 01:08 AM

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Dear lsmith, I would love more info on your diet plan. Does your husband take any supplements? Any info you can provide is certainly appreciated. My husband was diagnosed in January 2017 with GBM. He had two brain surgeries for removal of tumor in left frontal lobe. Besides GBM, he also has gliosarcoma and neuronal PNET in the tumor. All aggressive cancers. Kindest regards, Tammy

RE: Survival rates for Glioblastoma Multiforme Stage IV

by rbernacki on Wed Apr 26, 2017 10:01 PM

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Congratulations!  Great News for us all!

RE: Survival rates for Glioblastoma Multiforme Stage IV

by vggoes on Mon May 08, 2017 06:16 PM

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On Jun 26, 2012 6:24 PM kat54 wrote:

Shucky, I'm sorry you find yourself here in BT World.  I first landed here in 1993 with GBMIV.  I have had two surgeries, radiation and stereotactic radiosurgery - same as gamma knife but no chemo.  When I was first diagnosed chemo didn't cross the brain blood barrier so I decided to hold that off as last resort. so far I haven't needed it.  my full story is on yasg.com "" target="_blank" rel="nofollow">http://yasg.com " target="_blank" rel="nofollow">yasg.com under bios.  you will also find long time survivor stories at virtual trials.com "" target="_blank" rel="nofollow">http://trials.com " target="_blank" rel="nofollow">trials.com .  my tumor was located in my right temporal lobe.  I felt just like you in the beginning.  be patient it gets better.  remember your brain has been sliced, diced, fried and marinated in a short period of time.  It will need time to heal.  I slept about 20 hrs a day regularly as mental fatigue was terrible.  after my second surgery I was totally blind. I drive now, play golf generally have a good quality of life even though I was never able to return to work.  Please tell your Dr.s toread the survivor stories and to quit giving such terrible statistics. 

Feel free to contact me anytime I wish you the very best and send prayers for strength and patience.  Kathleen

It still does not cross the brain barrier. They endrentch the body in the hopes that some goes through. There is a hopsital in CA that has successfully for the first time ever been able to give a targeted chemo to the tumor in the brain. the little girl was then cancer free. I'll look for the site and share. 

RE: Survival rates for Glioblastoma Multiforme Stage IV

by TammyHill on Tue May 30, 2017 12:12 AM

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On May 28, 2017 11:24 PM galaxy101 wrote:

http://cancer.unm.edu/2013/09/25/antiviral-drug-may-extend-s urvival-in-glioblastoma/"" target="_blank" rel="nofollow">http://cancer.unm.edu/2013/09/25/antiviral-drug-may-extend-s target="_blank" rel="nofollow">http://cancer.unm.edu/2013/09/25/antiviral-drug-may-extend-s

Thank you so much for sharing this article on the antiviral drug! I will discuss this with my husband's neuro oncologist. Besides GBM, my husband's tumor (left frontal lobe) also had gliosarcoma and neuronal PNET cancer types. Has anyone heard of a brain tumor with so many different types of cancer present within it?

RE: Survival rates for Glioblastoma Multiforme Stage IV

by galaxy101 on Fri Jun 02, 2017 05:08 AM

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RE: Survival rates for Glioblastoma Multiforme Stage IV

by TammyHill on Fri Jun 02, 2017 03:43 PM

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On Jun 02, 2017 5:08 AM galaxy101 wrote:

maybe it would help, too:

https://www.cancertutor.com/dandelionroot/ "" target="_blank" rel="nofollow">https://www.cancertutor.com/dandelionroot/ " target="_blank" rel="nofollow">https://www.cancertutor.com/dandelionroot/

Thank you for the dandelion root link. The article did say "it hasn't had luck with brain tumors." Of course, one could try it anyway. Kindest regards, Tammy

RE: Survival rates for Glioblastoma Multiforme Stage IV

by galaxy101 on Sun Jun 04, 2017 04:45 AM

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 https://www.ncbi.nlm.nih.gov/pubmed/24970314
 Tanshinone IIA inhibits the growth,
 attenuates the stemness and induces the apoptosis of human
 glioma stem cells.
 
 ===
 
 https://www.ncbi.nlm.nih.gov/pubmed/23929619
 The fruits of Maclura pomifera extracts
 inhibits glioma stem-like cell growth and invasion.
 Zhao D1, Yao C, Chen X, Xia H, Zhang L,
 Liu H, Jiang X, Dai Y, Liu J.
 Author information
 Abstract
 Glioma is the most common primary
 intracranial tumour. Recently,
 growing evidence showed that glioma
 possesses stem-like cells, which
 are thought to be chemo- and
 radio-resistant and believed to
 contribute to the poor clinical
 outcomes of these tumours. In this
 study, we found that stem-like glioma
 cells (CD133+) were
 significantly increased in neurosphere
 cells, which are highly
 invasive and resistant to multiple
 chemotherapeutic agents. From our
 natural products library, we screened
 48 natural products and found
 one compound, Pomiferin, which was of
 particular interest. Our results
 showed that Pomiferin could inhibit
 cell viability, CD133+ cell
 population, sphere formation, and
 invasion ability of glioma
 neurosphere cells. We also found that
 multiple stemness-associated
 genes (BIM1, Nestin, and Nanog) were
 down-regulated by Pomiferin
 treatment of glioma neurosphere cells.
 Taken together, our results
 suggest that Pomiferin could kill the
 cancer stem-like cells in glioma
 and may serve as a potential
 therapeutic agent in the future

===

 > http://www.lifeextension.com/Magazine/2014/2/Brain-Tumor-Tre
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/24072501 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/24072501
 > sideritis
 >
 > http://www.lifeextension.com/Protocols/Cancer/Brain-Tumor/Pa
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/25162007
 > Andrographolide induces apoptosis
 of C6 glioma cells via the
 > ERK-p53-caspase 7-PARP pathway
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/24704558
 > Cordycepin induces apoptosis of C6
 glioma cells through the
 > adenosine 2A
 receptor-p53-caspase-7-PARP pathway.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/19263218
 > Silibinin inhibits glioma cell
 proliferation via
 > Ca2+/ROS/MAPK-dependent mechanism
 in vitro and glioma tumor
 > growth in vivo.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/23842993
 > Salvianolic acid B induces
 apoptosis in human glioma U87
 > cells through p38-mediated ROS
 generation
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/20358478
 > Mulberry fruit (Moris fructus)
 extracts induce human glioma
 > cell death in vitro through
 ROS-dependent mitochondrial
 > pathway and inhibits glioma tumor
 growth in vivo.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/26743778
 > A preliminary study of apoptosis
 induction in glioma cells
 > via alteration of the
 Bax/Bcl-2-p53 axis by transformed and
 > non-transformed root extracts of
 Leonurus sibiricus L.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/26560814
 > Nobiletin, a Polymethoxylated
 Flavone, Inhibits Glioma Cell
 > Growth and Migration via Arresting
 Cell Cycle and
 > Suppressing MAPK and Akt
 Pathways.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/26520377
 > Plumbagin alters telomere
 dynamics, induces DNA damage and
 > cell death in human brain tumour
 cells.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/26060537
 > The effect of yacon (Samallanthus
 sonchifolius) ethanol
 > extract on cell proliferation and
 migration of C6 glioma
 > cells stimulated with fetal bovine
 serum.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/25998182
 > Rhodiola crenulata inhibits
 Wnt/β-catenin signaling in
 > glioblastoma.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/25954855
 > Paeoniflorin inhibits
 proliferation and induces apoptosis of
 > human glioma cells via microRNA-16
 upregulation and matrix
 > metalloproteinase-9
 downregulation.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/25736407
 > Pterostilbene suppressed
 irradiation-resistant glioma stem
 > cells by modulating GRP78/miR-205
 axis.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/25527158
 > Fisetin suppresses ADAM9
 expression and inhibits invasion of
 > glioma cancer cells through
 increased phosphorylation of
 > ERK1/2.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/25409926
 > Biphasic effects of luteolin on
 interleukin-1β-induced
 > cyclooxygenase-2 expression in
 glioblastoma cells.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/25384233
 > Genistein alleviates
 β-amyloid-induced inflammatory damage
 > through regulating Toll-like
 receptor 4/nuclear factor κB.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/26788112
 > Saw Palmetto Extract Inhibits
 Metastasis and
 > Antiangiogenesis through STAT3
 Signal Pathway in Glioma
 > Cell.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/26208698
 > Withania somnifera Suppresses
 Tumor Growth of Intracranial
 > Allograft of Glioma Cells.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/25906387
 > Escin reduces cell proliferation
 and induces apoptosis on
 > glioma and lung adenocarcinoma
 cell lines.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/25785932
 > Ruta graveolens L. induces death
 of glioblastoma cells and
 > neural progenitors, but not of
 neurons, via ERK 1/2 and AKT
 > activation.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/25385044
 > Oligomer procyanidins (F2)
 isolated from grape seeds
 > inhibits tumor angiogenesis and
 cell invasion by targeting
 > HIF-1α in vitro.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/24945373
 > Serenoa Repens Induces Growth
 Arrest, Apoptosis and
 > Inactivation of STAT3 Signaling in
 Human Glioma Cells.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/24940902
 > Inhibitory effects of a
 polysaccharide extract from the
 > Chaga medicinal mushroom, Inonotus
 obliquus (higher
 > Basidiomycetes), on the
 proliferation of human
 > neurogliocytoma cells
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/24205314
 > Aqueous ethanolic extract of
 Tinospora cordifolia as a
 > potential candidate for
 differentiation based therapy of
 > glioblastomas.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/23007975
 > Extract from mistletoe, Viscum
 album L., reduces Hsp27 and
 > 14-3-3 protein expression and
 induces apoptosis in C6 rat
 > glioma cells.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/22842701
 > Induction of apoptosis and
 reduction of MMP gene expression
 > in the U373 cell line by
 polyphenolics in Aronia melanocarpa
 > and by curcumin.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/22722712
 > Olea europaea leaf extract alters
 microRNA expression in
 > human glioblastoma cells.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/22057676
 > Scutellaria extract and wogonin
 inhibit tumor-mediated
 > induction of T(reg) cells via
 inhibition of TGF-β1
 > activity.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/21575697
 > Evaluation of hydro-alcoholic
 extract of Eclipta alba for
 > its anticancer potential: an in
 vitro study.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/20737659
 > Fructus ligustri lucidi extracts
 induce human glioma cell
 > death through regulation of
 Akt/mTOR pathway in vitro and
 > reduce glioma tumor growth in
 U87MG xenograft mouse model.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/20467782
 > Delayed growth of glioma by
 Scutellaria flavonoids involve
 > inhibition of Akt, GSK-3 and
 NF-κB signaling.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/20106643
 > Selective induction of apoptosis
 in glioma tumour cells by a
 > Gynostemma pentaphyllum extract.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/19483651
 > Honokiol-mediated inhibition of
 PI3K/mTOR pathway: a
 > potential strategy to overcome
 immunoresistance in glioma,
 > breast, and prostate carcinoma
 without impacting T cell
 > function.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/19427771
 > Suppressive effects of swainsonine
 on C6 glioma cell in
 > vitro and in vivo.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/21479478
 > Green tea extract,
 epigallocatechin-3-gallate, inhibits the
 > growth and invasive ability of
 human glioma cells.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/17848749
 > Inhibition of glioma cell line
 A-172 MMP activity and cell
 > invasion in vitro by a nutrient
 mixture.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/17685631
 > Propolin G, a prenylflavanone,
 isolated from Taiwanese
 > propolis, induces
 caspase-dependent apoptosis in brain
 > cancer cells.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/17599805
 > Alkamides from Echinacea inhibit
 cyclooxygenase-2 activity
 > in human neuroglioma cells.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/17296291
 > Antiproliferative effects of
 mitraphylline, a pentacyclic
 > oxindole alkaloid of Uncaria
 tomentosa on human glioma and
 > neuroblastoma cell lines.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/17176222
 > In vivo inhibition of growth of
 human tumor lines by
 > flavonoid fractions from cranberry
 extract.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/16987298
 > The natural compound
 n-butylidenephthalide derived from
 > Angelica sinensis inhibits
 malignant brain tumor growth in
 > vitro and in vivo.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/16914050
 > Anticancer activity of extracts
 derived from the mature
 > roots of Scutellaria baicalensis
 on human malignant brain
 > tumor cells.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/14520549
 > The potential for strategies using
 micronutrients and
 > heterocyclic drugs to treat
 invasive gliomas.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/11774029
 > Bromelain reversibly inhibits
 invasive properties of glioma
 > cells.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/10894362
 > Boswellic acids inhibit glioma
 growth: a new treatment
 > option?
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/1622143
 > Antitumor agent, physalin F from
 Physalis angulata L.
 >
 > http://www.ncbi.nlm.nih.gov/pubmed/24072501 " target="_blank" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/24072501
 > The mechanisms of in vitro
 cytotoxicity of mountain tea,
 > Sideritis scardica, against the C6
 glioma cell line.
 >
 > http://link.springer.com/article/10.1007/s13277-015-4714-2
 > A preliminary study of apoptosis
 induction in glioma cells
 > via alteration of the
 Bax/Bcl-2-p53 axis by transformed and
 > non-transformed root extracts of
 Leonurus sibiricus L.

RE: Survival rates for Glioblastoma Multiforme Stage IV

by TammyHill on Sun Jun 04, 2017 03:06 PM

Quote | Reply
Dear galaxy101, Thank you SO much for all the great links above! I am still reading through them. May God continue to bless you for your caring about others in sending this information! Tammy
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