high kappa/lambda free light chain ratios but normal SPEP/UPEP, CBC

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high kappa/lambda free light chain ratios but normal SPEP/UPEP, CBC

by smjustin on Fri Oct 05, 2012 05:42 AM

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I have been extremely fatigued.  I was diagnosed with stage 2 kidney disease recently.  I also have Type 2 diabetes, fatty liver, and a history of pancreatitis.  I've been getting some neuropathy symptoms and I've been sweating often during the day.

My docs tested my blood for monoclonal cells with the SPEP and my urine with the UPEP, and that was all normal. 

However, my kappa/lambda free light chain ratio was high (3.5 then repeated at over 6)....... the nephrologist and hematologist spoke and they want me to get an immunoglobulin test.

I'm concerned with just the free light chain ratio being so high.  What do they hope to find with the immunoglobulin test that they haven't seen before?  I think they are trying to rule out MM, hoping it has to do more with my liver issues.  But I know MM can cause this stuff, too :(

RE: high kappa/lambda free light chain ratios but normal SPEP/UPEP, CBC

by Quincypp on Fri Oct 05, 2012 12:40 PM

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i don't have any answers sorry - but wanted to let you know I too just had a FLC test and got a high ratio - mine was 2.4 and had a high Kappa level. My SPEP came back basicaly normal. My dr is sending me to a hematologist - go Oct 26. I have had a history of unexplained fever, night sweats, fatigue and generally not feeling well and gone through several tests. my new GP was very concerned about this ratio and said it is nothing to be ignored. He mentioned MM to me as well as getting a bone marrow biopsy. good luck to you - will post what my hema says.

RE: high kappa/lambda free light chain ratios but normal SPEP/UPEP, CBC

by smjustin on Sun Oct 14, 2012 02:45 AM

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Good luck to you, also

I did find out a little more - that my lambda light chains were low and kappa was normal.  I have a liver biopsy on Oct 19, and they are hoping that gives them some info to work with.  I think the heme/onc and my kidney doc are a bit confused by the labs.  I have no m-spike with the normal blood and urine tests and normal CBC.

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