Abnormal ratio but normal SPE?

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Abnormal ratio but normal SPE?

by Quincypp on Fri Oct 19, 2012 03:21 PM

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I am hoping this can be explained to me. I see my hema/onc next week (no diagnosis of anything yet) i have an abnormal lambda/kapp ratio (2.3) on my Free Light Chain test with the free kappa measuring 45.5 mg/L. But my SPE tests show only a slightly higher alpha globulin result different labs have different ranges - but am always just over the normal for either lab. Reading the MM Canada page it says the immoxification test will show your m spike as seen by the SPE - but I don't think i had that shown when they did my FLC. They did a immunoglobin assay that showed my IgA, IgG and IgM all within normal levels and totalling just under 15 g/L.  I also have a very high CRP level 41.7 mg/L it says should be under 8.  Anyways my question is this - does this mean I don't have an M-spike? Or the test wasn't done? Can you have a abnormal ration and not have an mspike? I was told by a very knowledgable person on here that the test should have shown a graph on my results - I am now understanding this a bit more so think my conclusion is correct that the test to show the mspike wasn't ordered. Just a little background - my first hema did the test but sent me to my family dr for follow up and then dismissed me as going thru early menopause without seeing the results of the FLC and my family dr has now retired - my new dr said this is a result that needs to be followed up and hence why I am going to a new hema.

As I said I see my dr on Friday (week today) and am just trying to get my questions organized and prepare better. I have also had a positive gallium scan for abnormal bone marrow activity but no BMT yet.

thanks for any replies

RE: Abnormal ratio but normal SPE?

by Quincypp on Tue Oct 30, 2012 04:44 PM

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well I saw my dr on Friday - turns out that the first hema didn't do all the tests - missing the immoxification test that would have identified the mprotein and if there was a spike. The dr isn't thinking this is MGUS or MM - rather Lupus. So we'll see - did more blood work - go back Nov 23. Did anyone go down this path first?

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