New Celldex Clinical Study - Rindopepimut / Avastin after Avastin failure

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New Celldex Clinical Study - Rindopepimut / Avastin after Avastin failure

by jjcsdaisy1 on Fri Mar 01, 2013 06:10 AM

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Hello,

My husband has just started the clinical study with Rindopepimut/Avastin.  He had a brain tumor removed October 2011 - front right - that was diagnosed as GBM.  His tumor was unmethylated and, after the initial radiation/chemo (Temodar), he was on a clinical trial for Avastin/Tarceva with no tumor growth found until this past December (2012).  At that time, he was tested for VGFRviii(?) expression and was allowed to begin a clinical (Celldex) utilizing the vaccine Rindopepimut and Avastin.  I was wondering if there were anyone following this message board that had any experience with the Rindopepimut trial at this time?  And...if they are part of the first (newly diagnosed) or second (refractive? for Avastin) arm and how they are doing?  What side effects they may be experiencing if any?

Lisa

RE: New Celldex Clinical Study - Rindopepimut / Avastin after Avastin failure

by pooliepoo on Fri Jul 19, 2013 05:15 PM

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Just read your post concerning the trial of avastin and rindopeimot .Hows it going. I'm very curious as I am now trying to evaluate options and rinedopeimut seems promising.

RE: New Celldex Clinical Study - Rindopepimut / Avastin after Avastin failure

by rmp1399 on Fri Jul 19, 2013 10:39 PM

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Hello....my mom is part of the celldex trial for newly diagnosed. Her tumor was also right frontal and was methylated. She was diagnosed this year in January and did the standard radiation and temodar for six weeks and once that was over she started the celldex trial along with the temodar ( 5days a month schedule). She receives the shots every month. She has done three rounds of them so far. The shots are received in the fatty part of the inner thigh. The doctors have prescribed topical numbing cream to apply before she gets them. They do six to eight small shots every time. She says it is a little sore but bearable. She has had no side effects to this other than the soreness. My sister, who lives with her, says she seems to be a little bit irritable the day after the shots, but nothing I've noticed in talking with her on the phone. Who knows if it is the soreness, just annoyed with having to deal with this or maybe it's the medication. Which would be a good thing because maybe it means she is getting the actual rindopepimut and not the placebo. I hope everything goes well.

RE: New Celldex Clinical Study - Rindopepimut / Avastin after Avastin failure

by rayshin on Mon Nov 03, 2014 03:00 PM

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On Mar 01, 2013 6:10 AM jjcsdaisy1 wrote:

Hello,

My husband has just started the clinical study with Rindopepimut/Avastin.  He had a brain tumor removed October 2011 - front right - that was diagnosed as GBM.  His tumor was unmethylated and, after the initial radiation/chemo (Temodar), he was on a clinical trial for Avastin/Tarceva with no tumor growth found until this past December (2012).  At that time, he was tested for VGFRviii(?) expression and was allowed to begin a clinical (Celldex) utilizing the vaccine Rindopepimut and Avastin.  I was wondering if there were anyone following this message board that had any experience with the Rindopepimut trial at this time?  And...if they are part of the first (newly diagnosed) or second (refractive? for Avastin) arm and how they are doing?  What side effects they may be experiencing if any?

Lisa

Lisa-

My brother-in-law was diagnosed with GBM December/2012, treated with surgery, radiation, Temodar, and now Avastin.  There is currently a phase II clinical trial for Rindopepimut that has an arm for patients who have been treated with Avastin, and my sister and I are interested. 

I hope your husband is still doing well on the Rindo/avastin combination. Can you tell me how they tested for the presence of EGFRviii?  Did they have to use his biopsy sample for the test?  Name of the test?  I know it's a very specialized test that many oncologists may not be familiar with.

I would appreciate any information you can give me about the Rindo trial.  Thank you very much.

RS

 

 

 

RE: New Celldex Clinical Study - Rindopepimut / Avastin after Avastin failure

by LauraHope on Tue Nov 04, 2014 12:38 AM

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My husband has been on the Celldex and Avastin trail for over one year.  He is doing very well and has had no side effects, other than fatigue. Although the NOs are not sure if it is the Avastin OR the Celldex OR the combination,  we are thrilled with his recovery.

Please PM me if you'd like more information.

RE: New Celldex Clinical Study - Rindopepimut / Avastin after Avastin failure

by rayshin on Thu Nov 20, 2014 02:26 AM

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On Nov 04, 2014 12:38 AM LauraHope wrote:

My husband has been on the Celldex and Avastin trail for over one year.  He is doing very well and has had no side effects, other than fatigue. Although the NOs are not sure if it is the Avastin OR the Celldex OR the combination,  we are thrilled with his recovery.

Please PM me if you'd like more information.

Laura-

Regarding the Rindopepimut trials, I have learned that the trial sites at Dana-Farber in Boston, and at Duke, are not accepting any new patients.  Do you know if this at all sites?  Is this the end of the trial, or just an interim period for data analysis?  If it is just an interim down-time period for data analysis, would your husband's oncologist happen to know if and when it will be re-opened to accept new patients?   I know these are kind of "inside-baseball" questions that you may not have the answers to, but was hoping your oncologist may be able to shed some light since your husband is in the trial.  We are trying to enroll a member of my family in the Rindo trial.  

Thank you so much for any information you can share.

RS

RE: New Celldex Clinical Study - Rindopepimut / Avastin after Avastin failure

by LauraHope on Thu Nov 20, 2014 03:51 AM

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I am not sure.  This is the trial that my husband is on, which looks like it is still open

http://clinicaltrials.gov/ct2/show/NCT01498328?term=ReACT&am

LoveJesusChrist LoveJesusChrist
(Inactive)

RE: New Celldex Clinical Study - Rindopepimut / Avastin after Avastin failure

by LoveJesusChrist on Thu Nov 20, 2014 04:18 AM

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On Nov 20, 2014 3:51 AM LauraHope wrote:

I am not sure.  This is the trial that my husband is on, which looks like it is still open

http://clinicaltrials.gov/ct2/show/NCT01498328?term=ReACT&ra target="_blank" rel="nofollow">http://clinicaltrials.gov/ct2/show/NCT01498328?term=ReACT&am

Thanks for sharing the information, Laura. May I ask you few questions ?

1/ So, your husband is currently still on Avastin every 2 weeks and CDX-110 injection once a month ?

2/ How frequently your husband is taking the MRI to know if the tumor is progressive or intolerant ?

3/ Do you have to pay anything for the trial ?

4/ Since you have experience with the ongoing trial for your husband, do you know any trial currently opens for inoperable GBM ?

I find Northwest Biotherapeutics is currently ongoing of Phase II trial of DCVAX-L, but not DCVAX-DIRECT which is for inoperable GBM treatment ?

http://www.clinicaltrials.gov/ct2/show/NCT00045968

Do you know any ?

Thank you, Laura

RE: New Celldex Clinical Study - Rindopepimut / Avastin after Avastin failure

by LauraHope on Thu Nov 20, 2014 12:42 PM

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Hello Friends - to answer your questions

1/ So, your husband is currently still on Avastin every 2 weeks and CDX-110 injection once a month ?  Yes,  he has been doing schedule of treatment this since May 2013.

2/ How frequently your husband is taking the MRI to know if the tumor is progressive or intolerant ?  MRIs are every 8 weeks

3/ Do you have to pay anything for the trial ?  The trial is free,  our insurance pays for the Avastin since it is FDA approved.

4/ Since you have experience with the ongoing trial for your husband, do you know any trial currently opens for inoperable GBM ?

My husband had two sugeries, one a biopsy in Nov 2012 and one resection of the tumor Dec 2012.  In April 2013 he had a regrowth and then we were told the tumor was inoperable.   To my knowledge the Celldex trial is for inoperable GBMs.

Hope some of this information helps.

LoveJesusChrist LoveJesusChrist
(Inactive)

RE: New Celldex Clinical Study - Rindopepimut / Avastin after Avastin failure

by LoveJesusChrist on Fri Nov 21, 2014 02:28 AM

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Thank you so much for your quick reply, Laura.

I am looking for a trial for inoperable GBM, but we have never ever done any surgery. Hope the Celldex trial that your husband is currently on will help.

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