Canine Bladder Cancer Final Stages

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RE: Canine Bladder Cancer Final Stages

by everley on Thu Jan 17, 2019 11:04 PM

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On Jan 17, 2019 10:32 PM JoCro0106 wrote:

On Mar 31, 2015 7:41 PM Litasmomma wrote:

My Lita used to do the same thing when she would pee. That low bark I will never forget. You will know and she will tell you when it's time. She will stop eating and you'll notice her diapers are not as full as they were. She will eventually stop drinking as her kidneys shut down and she will refuse even her most loved food and drink items. She will also not be able to poop anymore and may even yelp a little when trying to push. I even had Lita on a stool softener from the oncologist and it did help for a month but eventually the cancer will win and nothing will work anymore. Honestly, I didn't think I would know either and I kept having nightmares that she would start yelping in pain really loud and not stop and I would have to rush her to the vet in the middle of the night and put her to sleep all while she is screaming and yelping. This never happened, thank God, but it was a fear that I lived with as we got closer to the end. But you will know when it's just too much for her to fight anymore. She will let you know.
Tonight our beautiful Noodles was diagnosed with a tumour at the neck of her bladder, she has been given Metacam to slow down the growth and then we return to the vets in 5 weeks for another ultrasound to see if the tumour has grown. We are absolutely devasted, she’s only 7 and is still so full of fun. Her symptoms were/are urinating often but only actually dispersing small amounts. We are praying we have her for as long as possible but any advice or help would be greatly appreciated. Our vet has ruled out surgery ??.

JoCro I am SO sorry to hear about Noodles diagnosis. I know exactly how you feel right now. Tessa's tumor was near the neck of her bladder and also inoperable. My heart broke when I heard that. My vet said they "can" place a stint in the bladder if the tumor begins to get too large because what you don't want is to have the tumor block the neck of her bladder and she will be unable to urinate and her bladder could rupture which would be an emergency so you need to watch that closely. I never had to do the stint so I am not sure about the aftercare of having one but you may want to ask your vet about it. Tessa's tumor never responded to the Peroxicam and never shrank. We kept her on it just in case it was at least slowing the growth. She lived 2 years and 2 months from her date of diagnosis which I was beyond grateful for. I remember when the vet gave me the news I thought I was going to lose her within 6 months. But with this horrible disease you just don't know how long you have. Every pet is different. I know your girl is only 7 and that is so unfair. My heart goes out to you. We are all here for you to help in anyway we can. My best advice is to watch her closely, check her urine for blood and clots, make sure her urine isn't decreasing in quantity and of course spoil her rotten. Hugs. 

RE: Canine Bladder Cancer Final Stages

by ZippyBeta on Fri Jan 18, 2019 02:18 AM

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Make sure you protect stomach from ulcers if you are giving Metacam. Ask your Vet for advice.

RE: Canine Bladder Cancer Final Stages

by Jcancom on Fri Jan 18, 2019 02:48 AM

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You might consider 3-Bromopyruvate.

This is a quote from the first url below. "The rate of tumor necrosis due to 3BP treatment seems to exceed all known cytostatic drugs."

https://www.ncbi.nlm.nih.gov/pubmed/?term=22328020

3-BP has demonstrated extreme effects on cancers in these 2 human reports. The studies in mice resulted in profoundly extreme responses. The melanoma patient below, as opposed to the liver patient above (who received liver TACE), received an IV injection of 3-BP. If you look carefully at Figure 3B below on the right you will notice something very startling, the patient's LDH level almost went to zero. After the second combination dose of 3-BP and paracetamol, the tumor almost stopped all metabolism. This patient did not survive much past this to some extent because his tumor mass filled most of his lungs, but perhaps also due to TLS. TLS can occur when there is an overwhelming amount of cancer destruction.

The liver patient had a near fatal TLS experience as well. Other incidents with TLS and 3-BP have been reported. 3-BP has been shown to be an extremely powerful in some of the human patients treated with it.There are safety measures that could reduce this risk.     

A human clinical trial with 3-BP is expected to be filed to the FDA and possibly start over the short-medium term.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110469/

I hope that you find this information useful.

Best Wishes.

RE: Canine Bladder Cancer Final Stages

by JoCro0106 on Fri Jan 18, 2019 06:00 AM

Quote | Reply

On Jan 17, 2019 11:04 PM everley wrote:

On Jan 17, 2019 10:32 PM JoCro0106 wrote:

On Mar 31, 2015 7:41 PM Litasmomma wrote:

My Lita used to do the same thing when she would pee. That low bark I will never forget. You will know and she will tell you when it's time. She will stop eating and you'll notice her diapers are not as full as they were. She will eventually stop drinking as her kidneys shut down and she will refuse even her most loved food and drink items. She will also not be able to poop anymore and may even yelp a little when trying to push. I even had Lita on a stool softener from the oncologist and it did help for a month but eventually the cancer will win and nothing will work anymore. Honestly, I didn't think I would know either and I kept having nightmares that she would start yelping in pain really loud and not stop and I would have to rush her to the vet in the middle of the night and put her to sleep all while she is screaming and yelping. This never happened, thank God, but it was a fear that I lived with as we got closer to the end. But you will know when it's just too much for her to fight anymore. She will let you know.
Tonight our beautiful Noodles was diagnosed with a tumour at the neck of her bladder, she has been given Metacam to slow down the growth and then we return to the vets in 5 weeks for another ultrasound to see if the tumour has grown. We are absolutely devasted, she’s only 7 and is still so full of fun. Her symptoms were/are urinating often but only actually dispersing small amounts. We are praying we have her for as long as possible but any advice or help would be greatly appreciated. Our vet has ruled out surgery ??.

JoCro I am SO sorry to hear about Noodles diagnosis. I know exactly how you feel right now. Tessa's tumor was near the neck of her bladder and also inoperable. My heart broke when I heard that. My vet said they "can" place a stint in the bladder if the tumor begins to get too large because what you don't want is to have the tumor block the neck of her bladder and she will be unable to urinate and her bladder could rupture which would be an emergency so you need to watch that closely. I never had to do the stint so I am not sure about the aftercare of having one but you may want to ask your vet about it. Tessa's tumor never responded to the Peroxicam and never shrank. We kept her on it just in case it was at least slowing the growth. She lived 2 years and 2 months from her date of diagnosis which I was beyond grateful for. I remember when the vet gave me the news I thought I was going to lose her within 6 months. But with this horrible disease you just don't know how long you have. Every pet is different. I know your girl is only 7 and that is so unfair. My heart goes out to you. We are all here for you to help in anyway we can. My best advice is to watch her closely, check her urine for blood and clots, make sure her urine isn't decreasing in quantity and of course spoil her rotten. Hugs. 

Thank you so much for your reply, your advice is really helpful, I’m going to mention to the vet about the possibility of a stint. Thank you, once again. X

RE: Canine Bladder Cancer Final Stages

by mellen on Sun Feb 10, 2019 08:38 PM

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Hi everyone! I am so sad to hear all of these stories but find comfort in knowing we are not alone in our journey. On 7/27/18, our female weimaraner, Gracie was diagnosed with TCC.  She's 11 years old and has been a Type 1 diabetic for 3 years and she was always predisposed to UTI's.  So when she had accidents and blood in her urine we just figured it was another UTI.  The vet put her on antibiotics and then all was good until a few weeks later it was back.  This time he suggested we do an ultrasound.  We did and they found a tumor in the trigone area.  The radiologist and our vets agreed it was TCC based on the ultrasound.  They put her on Peroxicam, sucralfate and femotidine (Pepcid AC).  She's also on insulin (Vesulin) 2 x a day for the diabetes.  We had a repeat ultraound in October (3 mos after diagnosis) and as expected the tumor has grown.  In December she started to have an increase in blood in the urine...real blood - red and thick.  Her urine sample came back negative for bacteria.  So the "temp" vet (our normal one) was on vacation and they didn't put her on anything - just told us to monitor her.  Then over another weeks span it got worse..stringy and mucosy with clumps of clots in it.  She seemed uncomfortable but did not have a loss in appetite or change in behavior.  So I went back to the vet and they gave us antibiotics just to try it out in case the sample was skewed...WOW! Her urine cleared up, she was doing great! And then she finished the round of meds and it came back.  So they put her on antibiotics indefinately.  None of us understand why that is helping but it is..at least with the clots, stringy, bloody urine.  She still has a tinge of blood, pinkish and is doing well for the most part.  Some nights are horrible...she can't get comfy and has to go out several times a night (45 mins- 1 hr 15 mins).  Its difficult on us but she still acts like she's not in pain and has an appetite.  It has been a roller coaster for sure.  I came to this thread because I was trying to find out what to expect.  And that is probably one of the most frustrating parts of TCC in dogs.  It's not the same for every dog and you don't know what to expect.  Our vet is amazing and just a few weeks ago they (husband and wife team) told me to simply enjoy the time we have together because you will know when it's time.  And that is pretty much what everyone else says.  I guess when she stops eating and/or is in pain we will have to make that choice.  I feel guilty saying that I just hope she passes in her sleep when it happens so I don't have to make the decision.  But chances are slim that it will end that way - at least reading all of these posts.  Anyway, I don't know if this helps anyone but maybe if you see the increase in blood, clots and stringy, mucousy bloody urine - ask your vet about antibiotics. (Clavomox)....it's working for us (for now).  In the meantime, hugs to all of you and your furbabies. 

RE: Canine Bladder Cancer Final Stages

by ZippyBeta on Sun Feb 10, 2019 11:50 PM

Quote | Reply

Iwas told the bloody thick discharge with clots is from the tumor shedding. Have you looked into Cranimals I enclosed the link, they worked for my girl.

                                      https://petretailworld.com/veterinary-trial-confirms-cranima

RE: Canine Bladder Cancer Final Stages

by Litasmomma on Mon Feb 11, 2019 03:14 AM

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I'm so sorry to hear about your little Gracie. This disease truly is horrible but I'm so happy I started this post to help everyone try to understand the ins and outs of this rollercoaster ride that is TCC. They kept Lita on Clavamox along with Peroxicam and she survived a lot longer that her prognosis. Just please give Gracie as much love as possible and know that whatever decision you ever decide to make in regards to her treatment will be the right one. Hugs and prayers. 

RE: Canine Bladder Cancer Final Stages

by Helenpatricia on Mon Feb 11, 2019 08:05 PM

Quote | Reply

On Feb 10, 2019 8:38 PM mellen wrote:

Hi everyone! I am so sad to hear all of these stories but find comfort in knowing we are not alone in our journey. On 7/27/18, our female weimaraner, Gracie was diagnosed with TCC.  She's 11 years old and has been a Type 1 diabetic for 3 years and she was always predisposed to UTI's.  So when she had accidents and blood in her urine we just figured it was another UTI.  The vet put her on antibiotics and then all was good until a few weeks later it was back.  This time he suggested we do an ultrasound.  We did and they found a tumor in the trigone area.  The radiologist and our vets agreed it was TCC based on the ultrasound.  They put her on Peroxicam, sucralfate and femotidine (Pepcid AC).  She's also on insulin (Vesulin) 2 x a day for the diabetes.  We had a repeat ultraound in October (3 mos after diagnosis) and as expected the tumor has grown.  In December she started to have an increase in blood in the urine...real blood - red and thick.  Her urine sample came back negative for bacteria.  So the "temp" vet (our normal one) was on vacation and they didn't put her on anything - just told us to monitor her.  Then over another weeks span it got worse..stringy and mucosy with clumps of clots in it.  She seemed uncomfortable but did not have a loss in appetite or change in behavior.  So I went back to the vet and they gave us antibiotics just to try it out in case the sample was skewed...WOW! Her urine cleared up, she was doing great! And then she finished the round of meds and it came back.  So they put her on antibiotics indefinately.  None of us understand why that is helping but it is..at least with the clots, stringy, bloody urine.  She still has a tinge of blood, pinkish and is doing well for the most part.  Some nights are horrible...she can't get comfy and has to go out several times a night (45 mins- 1 hr 15 mins).  Its difficult on us but she still acts like she's not in pain and has an appetite.  It has been a roller coaster for sure.  I came to this thread because I was trying to find out what to expect.  And that is probably one of the most frustrating parts of TCC in dogs.  It's not the same for every dog and you don't know what to expect.  Our vet is amazing and just a few weeks ago they (husband and wife team) told me to simply enjoy the time we have together because you will know when it's time.  And that is pretty much what everyone else says.  I guess when she stops eating and/or is in pain we will have to make that choice.  I feel guilty saying that I just hope she passes in her sleep when it happens so I don't have to make the decision.  But chances are slim that it will end that way - at least reading all of these posts.  Anyway, I don't know if this helps anyone but maybe if you see the increase in blood, clots and stringy, mucousy bloody urine - ask your vet about antibiotics. (Clavomox)....it's working for us (for now).  In the meantime, hugs to all of you and your furbabies. 

So sorry to hear about Gracie. It’s a horrid condition. We sadly had to let our Shadow go in November - 6 months after diagnosis. He was happy and pain free right to the end. As others have said on here, you will know when the time comes. With Shadow, he started passing much thicker clots and then couldn’t pass urine at all. This was over a period of a day. he had energy and a great appetite right to the end (he was very spoiled and ate better than we did!) The hardest thing I’ve ever had to do but I knew the time had come and I didn’t want him to have any more distress. We miss him so much. I hope you have much more time with her - Give her loads and loads of cuddles and enjoy every minute. Helen x

RE: Canine Bladder Cancer Final Stages

by everley on Wed Feb 13, 2019 12:42 AM

Quote | Reply

On Feb 10, 2019 8:38 PM mellen wrote:

Hi everyone! I am so sad to hear all of these stories but find comfort in knowing we are not alone in our journey. On 7/27/18, our female weimaraner, Gracie was diagnosed with TCC.  She's 11 years old and has been a Type 1 diabetic for 3 years and she was always predisposed to UTI's.  So when she had accidents and blood in her urine we just figured it was another UTI.  The vet put her on antibiotics and then all was good until a few weeks later it was back.  This time he suggested we do an ultrasound.  We did and they found a tumor in the trigone area.  The radiologist and our vets agreed it was TCC based on the ultrasound.  They put her on Peroxicam, sucralfate and femotidine (Pepcid AC).  She's also on insulin (Vesulin) 2 x a day for the diabetes.  We had a repeat ultraound in October (3 mos after diagnosis) and as expected the tumor has grown.  In December she started to have an increase in blood in the urine...real blood - red and thick.  Her urine sample came back negative for bacteria.  So the "temp" vet (our normal one) was on vacation and they didn't put her on anything - just told us to monitor her.  Then over another weeks span it got worse..stringy and mucosy with clumps of clots in it.  She seemed uncomfortable but did not have a loss in appetite or change in behavior.  So I went back to the vet and they gave us antibiotics just to try it out in case the sample was skewed...WOW! Her urine cleared up, she was doing great! And then she finished the round of meds and it came back.  So they put her on antibiotics indefinately.  None of us understand why that is helping but it is..at least with the clots, stringy, bloody urine.  She still has a tinge of blood, pinkish and is doing well for the most part.  Some nights are horrible...she can't get comfy and has to go out several times a night (45 mins- 1 hr 15 mins).  Its difficult on us but she still acts like she's not in pain and has an appetite.  It has been a roller coaster for sure.  I came to this thread because I was trying to find out what to expect.  And that is probably one of the most frustrating parts of TCC in dogs.  It's not the same for every dog and you don't know what to expect.  Our vet is amazing and just a few weeks ago they (husband and wife team) told me to simply enjoy the time we have together because you will know when it's time.  And that is pretty much what everyone else says.  I guess when she stops eating and/or is in pain we will have to make that choice.  I feel guilty saying that I just hope she passes in her sleep when it happens so I don't have to make the decision.  But chances are slim that it will end that way - at least reading all of these posts.  Anyway, I don't know if this helps anyone but maybe if you see the increase in blood, clots and stringy, mucousy bloody urine - ask your vet about antibiotics. (Clavomox)....it's working for us (for now).  In the meantime, hugs to all of you and your furbabies. 

I am so sorry to hear about Gracie. This disease sucks. Any cancer does but it is so hard when your fur baby is sick. My Tessa lived 2 years and 2 months after diagnosis and honestly for 2 years and 2 months I wondered "how will I know when it's time?" I worried all the time because I never wanted her to be in pain or suffer. Of all of these stories my girl did pass away at home on her own. I have had to make that call with my other fur babies and you really do KNOW that it's time. I find it interesting that the antibiotics are helping with the mucus and bleeding. Tessa's got pretty bad. It was really awful to deal with everyday the things that she would pass. We did antibiotics hoping it would help with at least the mucus but in her case it did not. Gracie will let you know how she is feeling and all you can do is spoil her rotten and watch things closely. Enjoy her all you can! Hugs.

RE: Canine Bladder Cancer Final Stages

by mellen on Thu Mar 14, 2019 12:57 AM

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Good evening!  Over the past week or so we have noticed that Gracie has had a bit of a bloated stomach.  Some days she has no appetite and others she is ravenous.  We had at least 4 feedings last week that she was not interested in.  So my hubby made a vegetable, bison and beef concotion that we mix with her commercial food and she has really enjoyed it.  She normally has pretty loose skin on her belly but we have noticed that she's been bloated - like her belly is full but we know there is not much in there.  Has anyone else noticed that with their pups with TCC?  Thank you.... <3

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