FOLFIRINOX vs ABRAXANE/Gemcitabine

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RE: FOLFIRINOX vs ABRAXANE/Gemcitabine

by lestom on Tue Sep 09, 2014 03:25 PM

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On Jul 29, 2014 10:12 PM meah1 wrote:

Thanks to both of you for that site...lots of info there.

Like I said before jobyu24, they started my husband off on folfirinox  as the 1st line treatment. Onc said it was the hardest hitting out there and from the side effects you would have thought so, but the tumor liked it and grew on it. Guess there's no telling until you try something.  Gemzar.abraxi "" target="_blank" rel="nofollow">http://Gemzar.abraxi " target="_blank" rel="nofollow">Gemzar.abraxi ne combo did shrink it some. Kinda seems to me it;s all a big crap-shoot. I don't think even the Drs. know.

My husband has 1V.PC .

We discussed the chemo that would suit Tom and in the end we went for ABRAXANE/Gemcitabine combo.

This week he will be having his 3rd session and thank God, Tom has had no noticible side effects.

He is having 3weeks on and 1 off, I don't know when the hair loss will happen, I also would like to know if with each session do the effects of the chemo build up.

RE: FOLFIRINOX vs ABRAXANE/Gemcitabine

by jobyu24 on Tue Sep 09, 2014 05:06 PM

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lestom -

My mom lost her hair about 3 days after her third treatment (she is also 3 on/1 off).  She didn't have ANY loss of hair, then poof - it started coming out.  3 days into that, we finally just shaved it off - which was emotional, but very, very liberating at the same time.

She also has had nausea intensify, but they've been giving her a pre-med in her port to help with that and she also has zofran and compazine (sp?) to use at home in addition.  It is not fun, but manageable.  Besides occassional nausea, her only other issue is fatigue and her taste being off.  I'll take these things over the pain though, anyday.

RE: FOLFIRINOX vs ABRAXANE/Gemcitabine

by jobyu24 on Tue Sep 09, 2014 05:11 PM

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Shasta38,

I am so glad you hear your husbands numbers are responding to your remedies!  I really hope you see the same positive result we've had with the gem/abrax.  I really believe finding a hopeful doctor and bringing as much positivity into your life is so essential in this fight... I was just as happy to hear my Mom's lowered number because of its meaning for the disease as I was knowing it would help bolster her (if that makes sense).  When she is up, it seems like things are more manageable and shes in a better place to help (allow) her body do it's work.

Keep fighting! 

RE: FOLFIRINOX vs ABRAXANE/Gemcitabine

by jobyu24 on Thu Oct 02, 2014 04:21 PM

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have to share great great news! We got my moms CT scan results today, the first CT scan after 8 weeks of treatment. Her liver spots have reduced dramatically, most are microscopic. Tumor... Is DISSOLVED and immeasurable!?! They said that the tumor tissue is indistinguishable with the pancreas tissue and cannot be measured any longer. It was previously four and a half centimeters at diagnosis. we are completely in shock with this news.  I kind of feel like I'm going to wake up and it is a dream, whereas the diagnosis was a nightmare I hoped to wake up from.

Prayers. .. and possibly OGX? Whatever the case, I am crying like a baby while thanking God for this miracle. 

They are going to reduce her chemo amounts so she tolerates them better - week 3 has been rough. However, with this news, my mom is nervous to change anything!  You can handle a lot of feeling like junk if the result is so phenomenal :)

RE: FOLFIRINOX vs ABRAXANE/Gemcitabine

by Hussy on Fri Oct 03, 2014 02:43 PM

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This is incredible news.  Thanks for sharing.

RE: FOLFIRINOX vs ABRAXANE/Gemcitabine

by maxxschiken on Wed Oct 08, 2014 09:00 PM

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Great news!  My question is if she is tolerating the current regimen with great success why disturb the dosage if this dose is what is bringing about great results? 

My wife had 19 rounds of folfirinox from August 2011 through May 2012 with no breaks.  Never an indication in her blood work to warrent a break from treatment so she pushed forward and this gave her almost 21 months of remission with no evidence of progressive metastatic disease.  I would think your Mom's oncologist would keep her on the same program until she reaches this point. 

Her cancer antigen CA19-9 scores went from 71,000 to below 17 and remained there until late 2013. She stopped all treatments in May 2012 with only quarterly CTscans and monthly blood work performed.  Her first recurrence came in January 2014 but not to the primary sites of her cancer (body of the pancreas and liver) which remain to this day clear. 

The first recurrence was to the lumbar region of her spine.  Began a modification of folfirinox called folfox (minus irrenotecan the strongest component in the folfirinox cocktail) with great quality of life and good results.  

After 3-4 months of folfox, PET/CT could no longer dectect the cancer in her spine, liver and pancreas remain clear.  CA-19's were at 9,000 in January of this year, on folfox came all the way down to 850, then last August began to climb at a rate of 100-200 points every two weeks.  CTscan in September discovered her liver, pancreas and spine continue to be clear. 

Two nodules in her lungs which were originally detected sometime in late 2012 have now started to grow.  Folfox was changed to Folfiri (5fu and irrenotecan) started 3 weeks ago.  Hoping this will keep the nodules from increasing in size.  The added irrenotecan which she has not tasted in almost 30 months is a tough one.  She has no good days after her first round and today, she just finished her 2nd round and still feels weak.  Hoping she will be come better acclimated to folfiri and show signs of feeling better. 

Her 8-9 months on folfox were exceptional quality of life.  We moved to a new home, she designed, built and cultivated a new backyard patio and garden and helped me furnish and decorate just under 1700 square feet of living space.  She will take a trip over-seas to the Philippines from December 5 through January 8 and I really want her to enjoy every minute of it!  Hoping and praying....

RE: FOLFIRINOX vs ABRAXANE/Gemcitabine

by jobyu24 on Thu Oct 09, 2014 01:42 AM

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The third week of treatment has been very, very hard on her.  Her bloods counts drop by that week which results in a Lunesta shot (I think that is the name of it...) which has awful side effects in addition to the fatigue/exhaustion the chemo entailed.  So, week three the past two months has resulted in her being absolutely and completely miserable, to the point of wanting to quit.  Needless to say, finding out her amazing results bolstered her to endure it - but our oncologist seemed to see no worry with cutting back on the chemo amounts themselves to help her tolerate it better, longer-term.  We can always adjust and I plan to discuss the amounts with our Oncologist at Vanderbilt next week (we have two Oncologists we're seeing... one with the treatment, one we trust as the expert... we had already started the trial with the one hospital before finding the expert...).  

THank you so much for sharing your wife's experience.  It is so helpful to hear others' stories and I will continue to share ours as we continue on.  I hope your wife does start to acclimate to the new treatment and get to enjoy her trip!

Speaking of - more great news.  We got her current CA19-9 back on Monday and it is down to 51!   After just 8 weeks of treatment.  We're estatic.

 

RE: FOLFIRINOX vs ABRAXANE/Gemcitabine

by maxxschiken on Thu Oct 09, 2014 01:15 PM

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oh okay... i didn't realize her blood counts were down and she was getting the Lunesta.  so this explains cutting back which is what her body most importantly her bone marrow to recover and give her the strength to continue treatment. 

from about my wife's 6th month of folfirinox treatment until her 10th and final month of that regimen, while her blood work was always good her oncologist still gave her Neupogen shots which has the same effect and similar side-effects as Lunesta.  My wife had this nagging bone and muscle aches during her week off treatment when the shots were administered 3-4x in that week off chemo.  We are in California and at the time our oncologist prescribed medically approved cannibis which we used briefly and with good results took away all of the discomfort from the shots.

oh btw, what is the name of the trial?  I seem to have missed it somewhere.... I thought she was on folfirinox or gemzar/abraxane...

jeffB 

RE: FOLFIRINOX vs ABRAXANE/Gemcitabine

by jobyu24 on Thu Oct 09, 2014 05:39 PM

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She is getting gem/abraxane and the trial drug is OGX-427. It's a phase 2 trial, it is supposed to inhibit a certain heat shock protein... Its a blind trial, so she could have had a placebo but we do believe she is getting the drug.  Considering the success she is seeing, I am definitely concerned with longevity and hope the reduction will allow that. We definitely don't want to quit the OGX anytime soon! 

RE: FOLFIRINOX vs ABRAXANE/Gemcitabine

by Dabag1964 on Thu Mar 12, 2015 05:52 PM

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On Sep 09, 2014 1:05 PM Shasta38 wrote:

I am so glad to read that your mom responded to the Abraxane/Gemzar. My husband has been on Folfox since July and his CA 19-9 continued to climb. Last week it dropped 8,000 points which we believe is from alternative treatments CBD oil, turmeric, Chaga, and ginger root. He's also been drinking Watt-Ah water. Yesterday was his first dose of Abraxane/Gemzar so we are hoping his numbers start to decline even more. They went from 5,550 in June to 24,600 in Aug! Now they are 16,000. He was given a 4 month sentence in June and the docs were very negative. We went to two other docs and found one in July That was Very hopeful.we "" target="_blank" rel="nofollow">http://hopeful.we " target="_blank" rel="nofollow">hopeful.we just spent the weekend at the Ritz Carlton with our daughter son in law and grand daughter!! Keep the faith. We will not give up!!! Shasta

May I ask if your husband has any side effects from Abraxane/Gemzar?

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