Has anyone's inoperable tumour shrunk completely from chemo

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RE: Has anyone's inoperable tumour shrunk completely from chemo

by maxxschiken on Thu Oct 16, 2014 09:48 PM

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Indeed!  My wife Annie was diagnosed with inoperable stage 4 adenocarcinoma of the pancreas with liver metastisis in July 2011.  Annie had a 5cm tumor on the body of her pancreas and two less then 1cm lesions on her liver.

While her oncologists and pancreatic specialists at both Stanford Medical Center and UCSF contend there is no known chemotherapy capable of doing what it did to my wife, the fact is she is living today 39 months post diagnosis and both her liver and pancreas are clean.

She tolerated 10 months/19 rounds of treatments without interruption. She never needed to take a break as her blood work always indicated she was tolerating it well. After her third round of treatment which she started in August 2011, her liver panels were normal. After 4 months of treatment her first CTscan could no longer see the lesions on her liver, both just vanished. The 5cm tumor reduced in size to 4mm.

She continued for another 6 months of folfirinox, her tumor markers which were at 71,000+ at diagnosis were down to 17, her second PET/CTscan in May 2012 showed a clean liver AND the 4mm tumor on the body of her pancreas became 'scar tissue' with no metabolic activity. She was declared to be with no evidence of new or progressive metastatic disease and no tumor recurrence. She enjoyed nearly 2 years of remission with no chemotherapy treatments only taking Metformin for her type 2 diabetic condition and Epivir to keep her liver healthy.

So to answer your question, my wifes not only shrunk completely but it became dead scar tissue. Her tumor and liver have shown no evidence of new or progressive metastatic disease since May 2012.  There are studies as of around 2012 which show some pancreatic cancer patients who took Metformin had better results with its use with standard chemotherapy.  Apparently the Metformin targets cancerous stem cells not eradicated by chemotherapy and also prevents tumor recurrence.  They are using Metformin with non-diabetic patients with all stages of cancers and not just cancers of the pancreas. 

RE: Has anyone's inoperable tumour shrunk completely from chemo

by phman10 on Thu Oct 16, 2014 09:58 PM

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Yes it does and can happen.  It is now seven years since my wife was diagnosed with Stage IV Pancreatic Cancer that also spread to part of her liver.  She is doing well, and has maintained a strong spirit and a sense of humor, and a belief in G-d and family.

RE: Has anyone's inoperable tumour shrunk completely from chemo

by Carien on Thu Oct 16, 2014 10:25 PM

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On Oct 16, 2014 9:58 PM phman10 wrote:

Yes it does and can happen.  It is now seven years since my wife was diagnosed with Stage IV Pancreatic Cancer that also spread to part of her liver.  She is doing well, and has maintained a strong spirit and a sense of humor, and a belief in G-d and family.

Hi Paul I read up on your posts, great to read that story. How long ago is it now since she had the whipple ? Carien

RE: Has anyone's inoperable tumour shrunk completely from chemo

by Tan1980 on Sun Oct 19, 2014 07:09 AM

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Thank you for your reply I have read a lot of your post on here your wife sounds like an amazing strong minded and positive person as do you like my mum, my mum tells me I have been her rock through this but she has been mine, my mum is my best friend and she makes me so proud of her with each and every day, I wish I had found this site in the beginning 12 months ago when the horror began until I did so much research I didn't think there was any hope, sometimes I have had a bad day with negative thoughts and places like this can bring you back to the positive frame on mind my mum is always so positive and it just amazes me, as I have said previously her oncologist is not very positive and doesn't explain things as well as other oncologist might do but due to being rural we don't have a choice she has traveled once further away ten hours round trip for a second opinion and he was so good he spent well over an hour with us so caring and so straight forward and explained things until we understood and also the main thing didn't shut us down with our questions and with my mums chinese medicine and believes in it and the diet as mums other oncologist is not interested in diet or other remedies and tells mum not to do it, mum is completely no red meat, no sugar no dairy and only wholemeal or wholegrain products and limited fish and poultry and plenty of fresh fruit and veg organic when we can which is very hard for where we live, as well as exercise and mediation no chemicals natural everything on processed food no microwave and well the list goes on and so much family love and support which is a massive thing to have so much support. So next week mum will have a ct to see if things are still stable now that her lung tumours are completely gone and the pancreatic tumour has not progessed in 12 months and if they are still good she will stop chemo and go on tablets I questioned her last appointment with stories like your wife's who's tumours had turned to scar tissue and stopped treatment and how do we know if it is completely scar tissue and can mum have a pet scan to see if it is active before she starts tablets and no she is not interested in mum having a pet scan and she is just ordering ct scan, how did the dr know that your wife's tumour had turned to scar tissue was it just the pet scan or did the ct scan give an indication that it was scar tissue also mums tumour markers have been rising the last couple of months but scans show everything is ok and her oncologist isn't too worried about this and I have read this can happen a lot and and also go the other way where markers are normal and cancer has progressed mum has tumour marker in a week so we will see whats going on she hasn't had one for about 6 weeks so not sure what they are at now, mum has had four cycles of gemcitabine at first then changed to folfirinox which she has had since April so not really sure where to from here and don't even know what the tablets she will start to take are as the oncologist doesn't go in to details of things until it happens but I am just so unsure if she sould go on tablets without having further test to see what is actually going on should my mum push for a pet scan or just go with the ct scan results I feel she sould push for pet scan your opinion would be greatly appreciated once again thank you Tanya

RE: Has anyone's inoperable tumour shrunk completely from chemo

by Tan1980 on Sun Oct 19, 2014 07:16 AM

Quote | Reply

On Oct 16, 2014 9:58 PM phman10 wrote:

Yes it does and can happen.  It is now seven years since my wife was diagnosed with Stage IV Pancreatic Cancer that also spread to part of her liver.  She is doing well, and has maintained a strong spirit and a sense of humor, and a belief in G-d and family.

Thank you for your inspirational story of your wife I pray for myself to be able to tell people fighting this terrible disease in years to come of my mum and how well she is doing, as she has now already done for 12 months

RE: Has anyone's inoperable tumour shrunk completely from chemo

by Tan1980 on Sun Oct 19, 2014 07:17 AM

Quote | Reply

On Oct 16, 2014 9:48 PM maxxschiken wrote:

Indeed!  My wife Annie was diagnosed with inoperable stage 4 adenocarcinoma of the pancreas with liver metastisis in July 2011.  Annie had a 5cm tumor on the body of her pancreas and two less then 1cm lesions on her liver.

While her oncologists and pancreatic specialists at both Stanford Medical Center and UCSF contend there is no known chemotherapy capable of doing what it did to my wife, the fact is she is living today 39 months post diagnosis and both her liver and pancreas are clean.

She tolerated 10 months/19 rounds of treatments without interruption. She never needed to take a break as her blood work always indicated she was tolerating it well. After her third round of treatment which she started in August 2011, her liver panels were normal. After 4 months of treatment her first CTscan could no longer see the lesions on her liver, both just vanished. The 5cm tumor reduced in size to 4mm.

She continued for another 6 months of folfirinox, her tumor markers which were at 71,000+ at diagnosis were down to 17, her second PET/CTscan in May 2012 showed a clean liver AND the 4mm tumor on the body of her pancreas became 'scar tissue' with no metabolic activity. She was declared to be with no evidence of new or progressive metastatic disease and no tumor recurrence. She enjoyed nearly 2 years of remission with no chemotherapy treatments only taking Metformin for her type 2 diabetic condition and Epivir to keep her liver healthy.

So to answer your question, my wifes not only shrunk completely but it became dead scar tissue. Her tumor and liver have shown no evidence of new or progressive metastatic disease since May 2012.  There are studies as of around 2012 which show some pancreatic cancer patients who took Metformin had better results with its use with standard chemotherapy.  Apparently the Metformin targets cancerous stem cells not eradicated by chemotherapy and also prevents tumor recurrence.  They are using Metformin with non-diabetic patients with all stages of cancers and not just cancers of the pancreas. 

Thank you for your reply I have read a lot of your post on here your wife sounds like an amazing strong minded and positive person as do you like my mum, my mum tells me I have been her rock through this but she has been mine, my mum is my best friend and she makes me so proud of her with each and every day, I wish I had found this site in the beginning 12 months ago when the horror began until I did so much research I didn't think there was any hope, sometimes I have had a bad day with negative thoughts and places like this can bring you back to the positive frame on mind my mum is always so positive and it just amazes me, as I have said previously her oncologist is not very positive and doesn't explain things as well as other oncologist might do but due to being rural we don't have a choice she has traveled once further away ten hours round trip for a second opinion and he was so good he spent well over an hour with us so caring and so straight forward and explained things until we understood and also the main thing didn't shut us down with our questions and with my mums chinese medicine and believes in it and the diet as mums other oncologist is not interested in diet or other remedies and tells mum not to do it, mum is completely no red meat, no sugar no dairy and only wholemeal or wholegrain products and limited fish and poultry and plenty of fresh fruit and veg organic when we can which is very hard for where we live, as well as exercise and mediation no chemicals natural everything on processed food no microwave and well the list goes on and so much family love and support which is a massive thing to have so much support. So next week mum will have a ct to see if things are still stable now that her lung tumours are completely gone and the pancreatic tumour has not progessed in 12 months and if they are still good she will stop chemo and go on tablets I questioned her last appointment with stories like your wife's who's tumours had turned to scar tissue and stopped treatment and how do we know if it is completely scar tissue and can mum have a pet scan to see if it is active before she starts tablets and no she is not interested in mum having a pet scan and she is just ordering ct scan, how did the dr know that your wife's tumour had turned to scar tissue was it just the pet scan or did the ct scan give an indication that it was scar tissue also mums tumour markers have been rising the last couple of months but scans show everything is ok and her oncologist isn't too worried about this and I have read this can happen a lot and and also go the other way where markers are normal and cancer has progressed mum has tumour marker in a week so we will see whats going on she hasn't had one for about 6 weeks so not sure what they are at now, mum has had four cycles of gemcitabine at first then changed to folfirinox which she has had since April so not really sure where to from here and don't even know what the tablets she will start to take are as the oncologist doesn't go in to details of things until it happens but I am just so unsure if she sould go on tablets without having further test to see what is actually going on should my mum push for a pet scan or just go with the ct scan results I feel she sould push for pet scan your opinion would be greatly appreciated once again thank you Tanya

RE: Has anyone's inoperable tumour shrunk completely from chemo

by Tan1980 on Sun Oct 19, 2014 08:02 AM

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On Oct 16, 2014 1:41 AM Titograndog wrote:

On Oct 15, 2014 10:31 AM Tan1980 wrote:

Hi my mum was diagnosised on the 31st oct last year so coming on 1 year in a couple of weeks which is not what we expected from the beginning until i research and seen so many stories of hope like the ones on here the Drs were so negative with this cancer from day one she was told she could be gone in as early as 8 weeks without chemo and with chemo upto 1 year or maybe longer and her prognosis no cure I haven't liked the oncologist since but unfortunely coming from a small rural community and do not have an option to see anyone one else unless she travels 5 hrs each way we have been once to a another one who was so much more caring and gave her more hope but couldn't offer her anything more then what she is already doing my mum has completely changed her lifestyle with food and exercise and also chinese medicine she has been fit and well people who find out what she has are amazed at how well she looks so mums cancer has not progressed in the last twelve months but has not gotten any smaller and the oncologist is stopping iv chemo and starting her on tablets if her ct scan still shows that everything is stable and I questioned her after reading lots of stories on the net about people's tumours completely going just from chemo and she said that this will not happen and the only way for it to go is surgically removed which is not an option for my mum, So hence my question her oncologist is just so negative and sad that I think I will now start to get my questions answered better here then from the one who should be answering our questions more better and not shut us which is what I feel she does all the time or doesn't explain thing to us that we can understand

Hold on as information fuels control and a great form of peace understanding your mums cancer.  Is your mother seeing an oncologist or primary care doctor?  Most oncologists will strive on providing hope even if they know the prognosis is not good.  When asked about life prognosis, the oncologist will share the most recent facts from the best medical studies done in the past year or two.   The very best that any cancer patient can hope for is a cancer FREE diagnosis.  There is no known absolute cure for any type of cancer.  Cancer free means that the most current form of scanning for cancer cells does not detect any problem.  I hope your mother is seeing an oncologist.  I would suggest that you get a copy of your mums pathology report which is like the bible of your mums type of cancer cells.  It will explain things like type of cancer, how aggressive the cells, the size of the tumor removed, the staging, if there is lymph node involvement and other very important pieces of information.  Your mum is entitled to have a copy of ALL test results.  Maybe try to make a consulting appointment with this doctor, you and your mum sharing with her than you are struggling understanding her medical terminology and could she communicate in more laymans terms.  You are absolutely entitled also to a second opinion even if it it just to consult with another doctor.  If the tumor was biopsied your mum may have lab slides sent to another oncologist for a nominal consult fee which insurance may cover.   The chosen doctor will review the slide and give you his best medical opinion.  Tissue slides are usually kept for seven years or longer so just have your mum call the hospital that did the biopsy and request tissue to be sent to another oncologist to confirm a second opinion.  It is so worth the support you might get from a second opinion.  Be very careful about what you read on the internet unless you are looking at sites like Stanford.edu "" target="_blank" rel="nofollow">http://Stanford.edu " target="_blank" rel="nofollow">Stanford.edu . Cornell, Northwestern and other great teaching hospital support sites.  Chose an oncologist that specializes in the treatment and study of you mums type of cancer. They are the most visionary with regard to treatment.  Oncologists each have their own chosen specialities.  You will have access to their profile in the site. It is true that the very best way to treat cancer is to surgically remove it but as you know that is not always possible.  Finding out that your mums tumor is not growing is great news but I would suggest asking, since the tumor is not operable is it is possible to do biomarker testing. Biomarkers are transforming cancer care.  This testing enables doctors to personalize their approach to dignosing and managing the disease.  Cancer biomarkers include identifiable gene mutations,proteins, growth factors and other biomolecules that can help in the diagnose and treatment process.  This testing will classify your mums tumor to determine ideal therapies or monitor patients treatment responses which for inoperable tumors can be invaluable.  Basically, this testing would identify the right biomarker which could affect the entire process of your mums cancer treatment.  You would most likely have to consult with a teaching hospital for this more advanced approach but so worth the simple blood test required.  Be sure to inquire on the insurance coverage.  Again hold on as cancer treatment is offering breakthroughs that already affect treatment for millions of people.  Maybe a gamma knife could remove your mums tumor.  Since I don't know the type of cancer, this is another suggestion.  I'm trying to give you hope for sure.  You are doing the right thing by becoming proactive in your mums treatment.  Knowledge fuels stability and understanding to prepare for life with cancer.  Chose your treatment with no regrets and get busy living in those priceless life moments.  Hold on to each other and know you are wished the very best.  Titograndog           

Thank you for all of this information yes my mum does see an oncologist but unfortunately she is not positive and she is a text book oncologist and with this cancer text books and studies are not positive so our other oncologist who we received 2nd opinion from but had to travel ten hrs to see him was not a text book dr and explained a lot to us that the other one had not, it was more so she only told us what we needed to here and not all the details which makes more sense when told everything and nothing held back and he was great spent well over an hour with him and gave us peace of mind that the oncologist we see might not be positive and have compassion and explain everything to us as a whole that mum was receiving the right treatment and if we, I already make sure I receive any copies of results and sometimes get more from these then her once again thank you for all this information

RE: Has anyone's inoperable tumour shrunk completely from chemo

by Tan1980 on Sun Oct 19, 2014 08:14 AM

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On Oct 15, 2014 11:18 AM Kjohnchas wrote:

Did they not offer,radiation? I think this is what shrunk my husbands,as he couldn't have surgery. I think chimo kept it from going anywhere else. I am sorry,I know too well how awful this disease is,,,,,,,god bless kathy
Thank you kathy radiation was going to be offered but they just did chemo first and when time came for radiation it had spread to lungs so they said radiation was now not an option but now the lung ones have completely gone with change of chemo which was very good news.

RE: Has anyone's inoperable tumour shrunk completely from chemo

by Tan1980 on Sun Oct 19, 2014 08:59 AM

Quote | Reply

On Oct 16, 2014 6:32 PM towjoe42 wrote:

I have had CLL Leukemia for 8 years and began taking Hemp Oil orally as shown on phoenixtears dot ca and now i am well below stage 0 with a WBC of 34,000 as of last week. I am taking it sporadically due to not always having enough Hemp Oil. I should be taking it three times a day, however the Hemp Oil I take is very psychoactive and I am still working driving a truck, so I only take it now once a day early in the evening. It also gives me a good appitite, sound sleep of 8-9 hours and usually do not have to get up to Pee. It also takes away all my pain from other issues. I am looking into another supply of Hemp Oil this time from theroc dot us in Colorado Springs, Co. It is from a variety of Non psychoactive Industrial Hemp called Charlotte's Web as seen on YouTube.

so glad you have been able to get this I have tried and spent $1000 dollars two months ago only to never receive held by customs but was worth the risk for my mum, I live in Australia and it is not legal but is in the process of becoming legal for the terminally ill I have done a lot of research on this and have purchased all ricks Simpson books and watched his documentary and it has amazing results all the best for you in your fight and anyone else who has the privilege of being able to receive this cured of oil

RE: Has anyone's inoperable tumour shrunk completely from chemo

by Tan1980 on Sun Oct 19, 2014 09:12 AM

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On Oct 15, 2014 11:53 AM tjvonblueberry wrote:

I am so sorry for your Mum and you.  My Mom was told she was not a candidate for surgery, chemo, radiation or anything else.  She was 82.5 years old when diagnosed.  They told her she had 10 months to one year and she died in 2 months.  I questioned why she cold not receive treatment, but based on what I read here and they told us the treatment may have been what killed her, so we opted for enjoying what time she had left.  Unfortunately, the cancer progressed rapidly and she died in two months.  In addition, she felt horrible for at least one of those months.  I will never know if she and us made the right decision, but I'm so glad she didn't suffer longer.  Each situation is different and if your Mum is young then I understand she may be more able to fight and withstand the treatment.  All you can do is the best you can.  I hope the treatment works for your Mum and you get quality of time with her.  I lost my precious Mom so fast that my head is still spinning.  Best wishes!

So sorry for your loss and they didn't do more for her my mum is 56yrs old and a real fighter and has been for the past 12 months and we have made as much as we can out of the last 12 months she has done so much in 12 months with many holidays and countless family coming and spending time with her she has been very well she does a lot of alternative treatment with her chemo from diet to Chinese medicine, apricot kernels and wheat grass shots and lots of mediation and exercise and many many prayers from so many people I pray your pain will ease with time I can't imagine life without my mum, my best friend and my world. Thank you for your well wishes Tanya
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