Immunotherapy after targeted therapy

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Immunotherapy after targeted therapy

by wanttolive on Wed Dec 16, 2015 08:01 PM

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Does anyone know if the immunotherapies currently available (like Opdivo or Keytruda) work well afer targeted therapy (like Tarceva), or less well?  I have two different doctors where one says it's the same, immunotherapy can work fine after tarceva stops working (if it stops), but the other doctor said it would be less effective.  The 2nd doctor also seems to want us to join an immunotherapy trial, so I don't know which one to trust.  We haven't yet found out if we are in a target group or not, but the 1st doctor seemed to indicate if we are in the target group we should definitely take the targeted therapy first, and then we can pursue the immunotherapy later.  He makes me feel the targeted is the way to go if possible, and the other makes me think the immunotherapy should be first.  Any thoughts/opinions?  Thanks Very Much for any help.

RE: Immunotherapy after targeted therapy

by Nigwar on Tue Mar 29, 2016 05:57 AM

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On Dec 16, 2015 8:01 PM wanttolive wrote:

Does anyone know if the immunotherapies currently available (like Opdivo or Keytruda) work well afer targeted therapy (like Tarceva), or less well?  I have two different doctors where one says it's the same, immunotherapy can work fine after tarceva stops working (if it stops), but the other doctor said it would be less effective.  The 2nd doctor also seems to want us to join an immunotherapy trial, so I don't know which one to trust.  We haven't yet found out if we are in a target group or not, but the 1st doctor seemed to indicate if we are in the target group we should definitely take the targeted therapy first, and then we can pursue the immunotherapy later.  He makes me feel the targeted is the way to go if possible, and the other makes me think the immunotherapy should be first.  Any thoughts/opinions?  Thanks Very Much for any help.

After six years with adenocarcinoma in the left lung, I've been on several treatments including Tarceva and Alimta.  Alimta has just stopped working for me so I've gone onto Opdivo.  Let me know if you'd like an update when I know if it is working.

RE: Immunotherapy after targeted therapy

by Deepwaters on Thu Oct 19, 2017 11:49 PM

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They are two different medications that work in two different ways. I can't tell you what is better, but I do know that immunotherapy is showing great promise. I am on Keytruda, but I don't know yet how effective it is or will be. Ill let you know when I do.

Deepwaters

RE: Immunotherapy after targeted therapy

by Devalzadvok8 on Fri Nov 10, 2017 06:16 PM

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Deepwaters, 

"They are two different medications that work in two different ways. I can't tell you what is better, but I do know that immunotherapy is showing great promise. I am on Keytruda, but I don't know yet how effective it is or will be. Ill let you know when I do."

Am at Stage IV lung cancer w/Malignant Pleural Mesothelioma.  Cancer type:  Epothelial.  Symptoms started in Dec 2012.  Current age:  83

Am currently on Keytruda, after having gone through 6 sessions of Alimta/Carboplatin.  Completed 3rd IV session this week.  Being run as a 'compassionate usage request' as otherwise my Medicare/Supplemental insurance wouldn't cover it.

Mesothelioma generally regarded as 'non-curable'.  Not much research and/or research money being spent in this area.

There is currently a Keytruda-only drug trial being run at the University of Chicago, but it is for Meso patients only.  The first 'arm' is complete and the 'second arm' is being run on those patients that are PD-L1 expression 'positive'.

The only feedback I can give you here is that the negative Keytruda side effects seem different than those of Alimta/Carboplatin, but no less serious.  There is a real question in my mind as to just how many chemo-type programs one can live through, due to both the side effects and how long they seem to last and where they leave the patient body's status.

My fourth session w/b  on Nov. 28th.  On Dec 5th I get a follow up PET Scan and should have the results back within a week.

I realize that my lung cancer may be different than yours, but the procedures recommended seem to be pretty much the same for other NSCLC cancers.

If my mind doesn't wander too much ( another side effect of both the chemo and Keytruda ) I will post an update of the results.

Rod

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