CandyTex's Message Board Messages

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My dermatologist told me efuddex/dovonex combo only reacts to areas where sun damaged skin is present and susceptible to skin cancer formation. My doc had me apply on my entire face and only certain areas reacted by reddening and peeling. I found treatment generally dries out skin wherever applies.

On Mar 23, 2019 10:16 AM Robincm wrote:

Hi CandyTex, Thankyou so much for the update. It certainly sounds as if the combination treatment is less agonising! Good luck with the results. Please do keep us updated again. I will certainly be talking to my Dr about trying it next time I need treatment. Picaro is just a 3 day treatment but is also very aggressive. Best regards, Robin

I finished my 2 wk treatment of efudex/dovenex combo (2x/day) at the end of March and here is feedback from my experience that might be helpful to others:

- keep your face moisturized as skin becomes very dryed. I used Ceraphil daily moisturiser as Aquaphor and Vaseline were too heavy. 

- redness begins early and scaling increases from day 7 to 15 and then rapidly continues for 4 to 5 days after that. I starts to improve day 21 and beyond.

- itching was almost the worst part of my experience with the red/soreness above my lips and on chin second. Over the counter Cortisone gel/cream 1% did not work for me. My dermatologist said she'd order me a prescription of stronger cortisone next time. 

- while you may initially see red blotches across your face, not all of these spots will end of scaling/peeling. It must means your immune system is working (per my dermatologist)

- expect that after you stop the treatment, you may not feel like things are improving. Hang in there, as after 4 to 5 days the relief comes pretty rapidly from symptoms.

My dermatologist said my face looks terrific. I am hopeful that I will not experience basal cell or squamous cell again. I may want to do this every 1 or 2 years to keep on top of emerging sun damage,

Good luck to everyone who is contemplating it. We all loved the sun, but didn't ever anticipate we'd be facing this cancer risk as we aged!

Hi Robin!

Thanks for your note. I've not heard of the Picato treatment.

I'm on my 12th day of treatment today, applying 2x/day over entire face. Here's what I've experienced:

Days 1-6:   Facial skin felt very dry. Very slight itching from day 3 forward.

Day 7-10: Red spots began appearing on forehead...hardly noticeable at first but progressively more pronouced as treatment proceeded along. Area above lipline and on chin started looking like a had a red rash. A bit tender but not bad. By Day 10 the redness was noticeable to me. This area of my face is a bit more senstive now and still feels dry. Still tolerable. 

Day 11-12: Red spotting more pronounced now with same areas of redness as mentioned above. Note...this is not the fiery red I've seen in other blog sites, just noticeable to me. Again slight itching which I merely tap on face with my finger to relieve. Still avoiding any moisturizers as the dryness is tolerable. I took 1 tablet of Tylenol 8hr arthritis last night at bedtime as a precaution and slept very well.

At this point, I'm feeling a bit self-conscious this last day about the red areas on face. Most times going into stores no one notices as they are too focused on their own business. Haven't tried applying make-up to cover redness...just haven't felt the need. I might consider it in future depending on circumstances when I leave the house. 

My first impressions is that the compounded lotion (efudex/dovonex) may be more tolerable than the straight efudex, but hopefully also more effective also. Some of the blogs show horrible redness which I haven't yet experienced.

I'll check back in a few days and report again. I'll be checking with my Dr. to see if she wants to extend treatment a 3rd week. I'd like to stop after the two weeks, so I can begin the healing process, but we'll see.

Take care and thanks for your inquiry.

RE: Efudex or Carac or Fluorouracil

by CandyTex - March 02 at 10:21 PM

On Mar 02, 2019 5:38 PM redintheface wrote:

Welcome to our group. I've never used this combination of the two and I don't believe I've read of anyone using it here. Some fast searches I found some information which I will be discussing with my dermatologist. 

https://www.mdedge.com/dermatology/article/109517/actinic-ke ratosis/adding-calcipotriene-5-fu-dramatically-reduced-aks"" target="_blank" rel="nofollow">https://www.mdedge.com/dermatology/article/109517/actinic-ke target="_blank" rel="nofollow">https://www.mdedge.com/dermatology/article/109517/actinic-ke

Good luck to you

Thanks for sending me the article...

Here' another link based on that same study:


I'd be interested in learning what your dermatologist says about this treatment combination. Maybe this is a breakthrough that will help others.

Hi everyone,

I am new to this discussion group but so happy to have found you all. Yup, fair hair/skin did me and years in the sun...lots of sunburn. But then it was called radiant..haha!

After two Mohs surgeries for basal cell and then squamous cell cancers, my Dr. prescribed treatment of Efudex/Dovonex lotion application...5 days to 10 days, depending on how I react. This is applied on whole face keeping eye zone and lips free of lotion.

I'm on day 2 and so far just a slight tightening of the skin on face. I know the worst is yet to come.

Just curious if anyone of you in this discussion have used this combined treatment which is supposed to provide more effective results per recent medical studies.

Thanks for everyone's support!

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