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Jcancom's Recent CancerCompass Activity

  • Jcancom has replied to a post on the message board

    There is some news that the thread should be made aware of.                                                            &...

    July 14 at 6:23 PM view post
    • Jcancom has replied to a post on the message board

      critic, the Calitheria and Nektar drugs are exciting! We are approaching the point where powerful FDA approved pharmaceuticals could be available to amplify other metabolic strategies. I am considering what might happen if CB-839 were to be combined with other metabolics. Glutamine, glucose, OXPHOS these are important cancer targets. What happens when all of them could be selectively turned off in cancer cells?

      July 14 at 1:38 AM view post
      • Jcancom has replied to a post on the message board

        critic, I reread the POH-3-BP article from 2017. It is simply stunning. There is no resistance! Everyone, Read the article, it's massive. If you have guaranteed unrestricted access to the interior of cancer cells, selectively, with a drug in the 3-BP universe that is pretty much game over as far as I see it. 3-BP attacks everything inside the cell: it's not pretty; some would like a more scientifically satisfying tr...

        July 10 at 2:18 AM view post
        • Jcancom has replied to a post on the message board

          JohnnyP, thank you for updating us! Of all the suggestions that I might give to you, remaining engaged with research into alternative treatment approaches would be at the top of the list, and I am very glad to see that you have remained so engaged. There are such an extraordinary number of treatment possibilities out there; you should never think that there is nothing left to try. I had not been aware of the combo th...

          July 09 at 2:35 AM view post
          • Jcancom has replied to a post on the message board

            JohnnyP, have you seen this one? https://onlinelibrary.wiley.com/doi/10.1002/hed.25492

            June 28 at 12:06 AM view post
            • Jcancom has replied to a post on the message board

              critic, Wow! More great news! It's everywhere. Pushing to over 1,000 mg daily intranasal dosing of POH! That is an extremely large dose considering the route of administration. With all that therapeutic index slack sitting there on the table, I am very interested to see what will happen when they go POH-3-BP intranasal.  Downdosing: I would tend to think that 1,000 mg of POH-3-BP intranasal would be well beyon...

              June 21 at 3:55 AM view post
              • Jcancom has replied to a post on the message board

                JohnnyP, it is such a joy to share in your successes! You are doing such a great job.There is an overwhelmingly large research base that can make cancer seem almost unknowable. That you have been able to extract the knowledge that you needed to help your wife inspires hope. I would tend to want to press forward, even in light of this good news, though it is often better not to exchange a known success for an uncerta...

                June 21 at 3:14 AM view post
                • Jcancom has replied to a post on the message board

                  Yes, critic, it surprises me as well that metabolic medicine continues to be at the periphery. When JohnnyP started mentioning the various chemotherapies I was at such a complete loss. Once the cancer resists then what? There have been some dramatic responses with some of the new class of pharmaceuticals (such as BRAF), and then there is resistance and then it's back to square one. Metabolic medicine offers a nearl...

                  June 18 at 12:44 AM view post
                  • Jcancom has replied to a post on the message board

                    This is so super exciting waiting and watching for the next step in metabolic medicine! Adding in one extra combo or in some way changing the route of administration or timing of dosing etc. could dramatically amplify metabolic responses. We saw this with the melanoma patient when they added paracetamol to 3-BP. The patients's truly extreme tumor burden almost immediately shut down metabolic activity. That was one o...

                    June 03 at 2:35 AM view post
                    • Jcancom has replied to a post on the message board

                      JohnnyP wanted to make sure that you were aware of this one. Very exciting in metabolic research when things are always popping out of nowhere. We have been aware for quite some time of the vitamin C doxy combo, but this one looks even better. You can never be quite sure when they might hit the combo that has extreme effectiveness. Those who have been oberving this for a while can recognize that there are a relativel...

                      May 22 at 2:17 AM view post
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