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JohnnyP's Message Board Messages

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RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP - February 11 at 5:39 AM

J:

I watched this video several months ago.  It's part of a series of six videos from a 2017 conference in Paris.  Most of them were pretty good, from people I've seen before.

This one by Ernest G. Hope is on immunotherapy that targets the blood vessels that feed the tumor:


https://www.youtube.com/watch?v=kDkuwW7Bqho&t=445s

Very exciting stuff, so I did a search on where to go get it, and found nothing.

The Holy Grail and no one is using it?

One of the slides in his presentation he says it's patented, so I did an advanced patent search under his name and found one patent, EP1231840B1.  The patent was granted in 2009, but is no longer in force. Status is "Ceased":

https://www.ipo.gov.uk/p-ipsum/Case/ApplicationNumber/EP0098


I posted a comment to that effect below the video, but all comments are now gone.

To me, it looks like a "vaporware" presentation about a lot of work he did that didn't pan out.

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP - February 02 at 2:15 PM

Shirley is doing great.  We just saw her radiation oncologist for a followup, scheduled four months ago.  The doctor and staff were very surprised at her progress.  When I asked, he said from her initial visit last May, her spine was so damaged they really didn't think she would make it to Christmas.

At one point, Shirley stood up out of her wheelchair and bent over to pull down her pants legs.  You should have seen the shocked face of the doctor's assistant.  She couldn't believe Shirley was able do that.

The doctor asked a lot of questions about how she is feeling, etc.  I told him I  was worried about the rising CA15-3 marker, but he said "I don't go by that.  I go by the clinical evidence and she is doing great.  The marker is just a blood number that rises and falls."

I asked how many MRI's and PET scans does our insurance allow per year?  He said he didn't know, but he would be glad to schedule a PET scan for her.  I think he said it would be a couple months.  Shirley later told me if he was really worried, he would have scheduled it right away.  I know, it's not really evidence. but it's something.

I asked if he had seen the materials I have been emailing, he threw up his hands and said he has no time to look at it.

We have both lost considerable weight since they last saw us, but it was needed and they sat we look great.  I reminded him we have been eating a low carb calorie restricted ketogenic diet.  My wife doesn't think they would mention it to their patients, but based on their reactions, she thinks they would try it themselves if they had cancer.

I'm still watching youtubes and reading papers.  I found a video from 2013 by Dr. George Yu, a colleage of Dr. Ko's.  He does mention 3BP at one point, and shows a photo of himself with Dr. Ko:

https://www.youtube.com/watch?v=om2Uj07ypec

I googled and see he has a foundation.  3BP is mentioned at the bottom of this page:

https://yufoundation.org/about-us

There are some links I need to follow at the very bottom.

Meanwhile, the Metabolic Conference is ongoing in Long Beach this week.  Dr. Seyfreid and Dr. D'Agastino will be there.  I can't wait to hear the latest news.

Oh, after the doctor's visit, Shirley wanted to have a look in the Goodwill store.  I wheeled her around and we both found a few things to take home.  In the book section, I scored a copy of "Molecular Biology of The Cell" third edition, 1991.  1294 pages plus glossary and index.  $1.95.  :)

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP - January 25 at 4:14 AM

Fig. 1:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289136/figure/

Very grim looking.

Two months ago I asked the oncologist about cases like this.  She said 18-24 months, but she has some still going after ten years.

And she doesn't want us to take curcumin???  I'm wasting my time doing all this research and sending it to them.

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP - January 25 at 3:04 AM

I bought nano curcummin for Shirley a few weeks ago, but she wanted to run it by the oncologist before taking it.  We asked about it today when we had our monthly consultation.  Today it was with a P.A. (physician assistant).

I gave her the bottle and she went away to ask her boss.  She returned to say "it's an anti-oxidant that might be ok for you and me, but we don't know how it will interact with her cancer medication, so no, don't take it.  It has to be proven with clinical trials."

ARRRRGGGG!!!!!!

They spend very little time with us.  I wanted to discuss the rising CA15-3 marker but no time.  I pulled out my phone and showed her the survival curve and asked where are we on this, we need to know.  She didn't answer and said she had to see other patients.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289136/

Scroll down to fig.1 or click here:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289136/ bin/jocmr-09-183-g001.jpg

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP - January 24 at 10:40 PM

Is anyone going to the Metabolic Health Summit in Long Beach this weekend?

I considered buying tickets for one of our oncologists but my wife said it would be a waste of money.

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP - January 24 at 3:51 PM

Hmm, a thread about "Methformin and Syrosingopine" on cancercompass.  Ten replies from 1/17 to 1/18:

https://www.cancercompass.com/message-board/message/all,9444

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP - January 24 at 3:36 PM

Doing a search I found this post about it here:

https://healthunlocked.com/advanced-prostate-cancer/posts/13

"cesanon
in reply topjoshea13
a month ago

Talked to my Doc about syrosingopine.

He thought it was a really bad idea. There is a reason no one uses it anymore.

It has really bad side effects. No one even appears to sell it anymore."

How bad is "really bad" compared to chemo, etc?

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP - January 23 at 7:10 PM

I found a 17 page paper on Metformin and Syrosingopine:

https://www.cell.com/cell-reports/pdf/S2211-1247(18)31806-0.pdf

It looks like there is still a lot of work to do on it.  What has Daniel done with it so far?

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP - January 22 at 7:44 PM

Wow, that is cool.  Two common, safe, affordable drugs all oncologists are probably familiar with when used for their original purpose.  But, very scary (to them) when used off label.

I wonder if Dr. Nagourney is trying this in his clinic in Long Beach.  He's already using Metformin.

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP - January 21 at 12:24 AM

I found this while searching for Metformin cancer videos a couple days ago:

https://www.youtube.com/watch?v=73xCwdB6m2k

It's from CBS2 News, published on youtube last month.

Original story titled "ONLY ON 2: Diabetes Drug That Kills Cancer?"

https://losangeles.cbslocal.com/video/3987524-only-on-2-diab

Dr. Robert Nagourney in Long Beach, CA

https://www.nagourneycancerinstitute.com/

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